Lecture 17: Early Lymphocyte Maturation - T Cells

Question 1

Thymus is derived from ____ cells

Answer 1

epithelial

Question 2

True or false:

The thymus increases in size with age.

Answer 2

False, the thymus involutes during puberty.

Question 3

γδ T cells are primary located at _____

Answer 3

epithelial and mucosal sites

Question 4

True or false:

γδ T cells express both CD4 and CD8

Answer 4

False, γδ T cells lack both CD4 and CD8.

Question 5

True or false:

γδ T cells under go positive selection.

Answer 5

False, γδ T cells do not undergo positive OR negative selection.

Question 6

During DN1, the cell starts expressing ____

Answer 6

CD25 (part of the IL-2 receptor)

Question 7

Addition CD25 to the IL-2 receptor has what effect?

Answer 7

Change from low affinity to high affinity

Becomes highly responsive to IL-2 - stimulates proliferation

Question 8

Recognition of specific peptide:MHC complex in the thymus leads to

Answer 8

deletion

Question 9

Recognition of specific peptide:MHC complex in the periphery leads to

Answer 9

activation