lecture 2 Flashcards
four cardinal signs of inflamation
heat redness pain swelling
three purposes of inflamation
remove pathogen, remove dead tissue, and start healing
what is the sings of acute inflamation
fluid and nuetrophils
what are present in chronic inflamation
macrophages and lymphocytes
four potential outcomes of inflamation
remove pathagen, wall it off forming an abscess, form a scar, or go into chornic inflamation
what forms the wall in an abscess
neutrophils
what is the immidiate response to inflamation
vasoconstiction
what is the process of acute inflamation
exposed basal membrane or collagen leads to realease of hageman factor that converts prekalikrinine to kalicrinen
during acute inflamation what causes the rolling phase of neutrophils
p selectin from the palad wiebal bodies is realeased and binds to the psgl 1 recepotor in the nuetrophils and slows them with the low affinity
what causes the neutrophils to enter the biding stage
icam from the endothelial cells binds to LFA 1 in the nuetrophils causes high affinity binding
what causes the neutrophils to enter extravasation
pecam or cd31 is always released by both neutrophils and endothelial cells and cause the neutrophils to leave
what does TGF beta do and where does it come from
macrophages realease it and it causes fibroblasts to come and start with collagen for scar tissue
what three processses happen simitanouly in chronic inlfmation
inflamation tissue destruction and deposition
outline the process of acute inflamation
WOW
outline the process of fever
you are so awesome
what does interluiken 6 do
it activates the liver to make acute phase reponse protiens especially c reactine
what effect does TNF have on the blood stream
it can create shock in times of sepsis
