Lecture 2 Flashcards
Dopamine
inhibitory neurotransmitter
Acetylcholine
Excitatory
Neurotransmitters
Protein created by nerve cells
Neurotransmitters
- Dopamine
- Adrenaline
- Noradrenaline
- ACh
- GABA
- Serotonin
- Glutamate
Dual activity
Central Nervous System
Peripheral Nervous System
Dopamine - Peripherally
Movement
Dopamine - Centrally
Reward
Parkinsons Diease
progressive disease of the NS
- tremor, muscular rigidity, and slow, imprecise movement.
Basil ganglia
contains substantia nigra
- synthesize dopamine
Extra Pyramidal Tract
spinal nerves, “highways” from the Basal Ganglia to the spinal cord
Classification
Primary: Idiopathic (unknown)
Secondary: Induced by head trauma, infection, tumors, drug exposure
Etiology
10% genetic
90% environmental
Parkinsonism (Reversible Parkinson), PsuedoParkinsonis, EPS
reversible
What causes Nausea?
Excess:
Dopamine - Antidop
ACh - AntiACh
Serotonin - Antisert
Histamine - Antihistamine -
Antipsychotics of major tranquillize
Methyldopa
Clonidine - Use to treat high blood pressure
Parkinsons S&S
do not include alterations of HR
S&S
- Tremors
- Dyskinesia
- Propulsive uncontrolled movement
- Akinesia
Rx
Levodopa
Normal
Increase Levodopa -> Increase Dopamine -> Decrease ACh -> Decrease GABA
Abnormal
Decrease Levodopa -> Decrease Dopamine -> Increase ACh -> Increase GABA
First treatment
MAO inhibitors:
Selegiline (Eldepryl)
rasagiline (Azilect)
***Neuro protector
Second treatment
Dopamine
Third Treatment
