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pharmacology i > Lecture 2 > Flashcards

Lecture 2 Flashcards

1
Q

Dopamine

A

inhibitory neurotransmitter

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2
Q

Acetylcholine

A

Excitatory

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3
Q

Neurotransmitters

A

Protein created by nerve cells

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4
Q

Neurotransmitters

A
  • Dopamine
  • Adrenaline
  • Noradrenaline
  • ACh
  • GABA
  • Serotonin
  • Glutamate
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5
Q

Dual activity

A

Central Nervous System
Peripheral Nervous System

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6
Q

Dopamine - Peripherally

A

Movement

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7
Q

Dopamine - Centrally

A

Reward

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8
Q

Parkinsons Diease

A

progressive disease of the NS
- tremor, muscular rigidity, and slow, imprecise movement.

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9
Q

Basil ganglia

A

contains substantia nigra
- synthesize dopamine

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10
Q

Extra Pyramidal Tract

A

spinal nerves, “highways” from the Basal Ganglia to the spinal cord

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11
Q

Classification

A

Primary: Idiopathic (unknown)
Secondary: Induced by head trauma, infection, tumors, drug exposure

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12
Q

Etiology

A

10% genetic
90% environmental

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13
Q

Parkinsonism (Reversible Parkinson), PsuedoParkinsonis, EPS

A

reversible

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14
Q

What causes Nausea?

A

Excess:
Dopamine - Antidop
ACh - AntiACh
Serotonin - Antisert
Histamine - Antihistamine -

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15
Q

Antipsychotics of major tranquillize

A
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16
Q

Methyldopa

A

Clonidine - Use to treat high blood pressure

17
Q

Parkinsons S&S

A

do not include alterations of HR

18
Q

S&S

A
  • Tremors
  • Dyskinesia
  • Propulsive uncontrolled movement
  • Akinesia
19
Q

Rx

A

Levodopa

20
Q

Normal

A

Increase Levodopa -> Increase Dopamine -> Decrease ACh -> Decrease GABA

21
Q

Abnormal

A

Decrease Levodopa -> Decrease Dopamine -> Increase ACh -> Increase GABA

22
Q

First treatment

A

MAO inhibitors:
Selegiline (Eldepryl)
rasagiline (Azilect)

***Neuro protector

23
Q

Second treatment

A

Dopamine

24
Q

Third Treatment

A
25
Q

Wearing off Phenomenon

A
26
Q
A

pharmacology i (5 decks)

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