Lecture 2

Question 1

Half-life

Answer 1

-time for half drug to be eliminated

Question 2

Higher Kel

Answer 2

-faster elimination
-shorter half-life

Question 3

Clearance

Answer 3

-constant relating rate of elimination and plasma
-based on volume of plasma eliminated not the drug concentration
-cannot exceed cardiac output

Question 4

Linear kinetics

Answer 4

-dose independent
-Kel, CL, Vd do not change
-double dose = double concentration

Question 5

nonlinear kinetics

Answer 5

-dose dependent
-Kel, CL, Vd change

Question 6

When the dose is higher for a drug with linear kinetics

Answer 6

Vd will not change

Question 7

In linear kinetics AUC is proportional to

Answer 7

DOSE

Question 8

As time passes after drug administration, Kel will

Answer 8

not change

Question 9

Kel estimated from data shown may be negative

Answer 9

FALSE
-K CANNOT be negative

Question 10

Which one of the following does not increase proportionally with the dose?
A. Drug concentration at time = 0
B. Drug concentration at time = 4 h
C. AUC
D. kel

Answer 10

Kel