Bioavailability and Clearance III + IV Flashcards
Beta blockers
-lower QH
-lower cardiac output
incressing CL
dec AUCiv
factors effecting F of low Eh drug
-none
factors affecting F in HIGH EH drug
-QH
-fu
-CLint
increasing CLint will
decrease F of high EH drug
Factors affecting AUC
factors affecting CL
CL and AUCiv move in
opposite directions
factors affecting AUCiv of low EH drug
-fu
-CLint
factors affecting AUCiv of high EH drug
-Qh
Oral clearance of low and high EH drugs
CL/F = fu x CLint
factors affecting AUCpo
-fu
-CLint
in both high and low EH drugs
CL and AUCpo move in
opposite directions
Weak base is ionized at
low pH
ionization of drug (polar, strong acids and bases)
-low reabsorption
-lower renal CL
unionized drug (weak acids and bases)
-higher reabsorption
-low renal CL
urine flow rate affects
reabsorption
urine pH affects
reabsorption
renal transporters affect
secretion
infusion vs multiple dosing
-jagged line
-reach similar steady state
filtration
-glomerulus
-depends on MW and fu
only unbound drug in plasma water is
filtered
secretion
-proximal tubule
-active-carrier mediated
-saturable
-not neurtal drugs
high ER drugs
-secretion only dependent on blood flow
low ER drugs
-secretion dependent only on fu
factors affecting renal absorption
-polarity
-ionization
-urine flow
-urine pH
increase urine flow
increases excretion
high plasma protein binding
decreases excretion
acidic urine
-reabsorption of weak acids
-inc CLr of weak base
basic urine
-reabsorb bases
-inc CLr of weak acid
