Lecture 19 - SLE

Question 1

Bc SLE causes high levels of autoAbs to be produced, this activates the _______ system, and the components of this system are eventually consumed. Thus, you should expect patients to present with high levels of autoAbs and HYPO________ (specifically low levels of C3 and C4).

Answer 1

Complement system

Hypocomplementemia

Question 2

_______, Procainamide, Isoniazid, and Minocycline are drugs that are commonly implicated in drug-induced SLE.

Answer 2

Hydralazine

Question 3

What is the most common organ affected in SLE pateints?

Answer 3

Kidney

Question 4

Patients presenting with low blood cell counts (termed ________) and other symptoms including fever, SLE should be considered.

Answer 4

Pancytopenia

Question 5

What is the most important test to identify SLE and which autoAbs are the most specific to SLE? Which autoAb is specific for Drug-induced Lupus?

Answer 5

ANA (anti-nuclear antibody). dsDNA and Smith antigen autoAbs are the most specific for SLE.

Histone autoAbs are specific for Drug-induced Lupus.

Question 6

Malar skin rashes on the face are common in patients with SLE, but they characteristically spare which area on the face?

Answer 6

The nasolabial region (under the nose and around the mouth.)

Question 7

What is the main demographic affected by SLE, and is the disease more or less severe in this population?

Answer 7

It is most common in female patients of childbearing age who are of minority ethnicity. It is typically more severe in minorities, but it is also typically more severe in males.

Question 8

Mouth sores and nasal sores are common in SLE patients. Are these sores typically painful?

Answer 8

No

Question 9

SLE patients often present with arthritis similar to RA patients, but the joints in SLE patients are typically not eroded. This is called _______ arthropathy.

Answer 9

Jaccoud’s arthropathy

Question 10

The most common cause of death in SLE patients is _____ _____ disease. Also be on the lookout for noninfectious endocarditis in SLE patients (this is called ____-___ endocarditis).

Answer 10

Coronary Artery Disease

Libman-Sacks endocarditis

Question 11

If you suspect an SLE patient has antiphoshpolipid syndrome, which 3 lab tests are you going to order to confirm antiphospholipid syndrome?

Answer 11

Anticardiolipin antibody, Lupus anticoagulant, and Beta 2 glycoprotein-1 antibody tests.

Question 12

The gold standard for SLE treatment is __________.

Answer 12

Hydroxychloroquine