Lecture 15 - Skeletal Muscle Relaxants

Question 1

GABA-A receptor agonism causes ____ influx, and thus hyperpolarization.

Answer 1

Chloride influx

Question 2

Presynaptic GABA-B receptor agonism inhibits ________ of neurotransmittiers (NTs), while the Postynaptic GABA-B receptor agonism promotes ______ efflux (and thus hyperpolarization.)

Answer 2

Exocytosis

Potassium efflux

Question 3

Diazepam (and all benzodiazepines) facilitate the activation of _____ receptors. ________, on the other hand, directly activate this receptor.

Flumazenil is an antagonist.

Answer 3

GABA-A

Barbituates

Question 4

Baclofen is a _____ receptor agonist.

Answer 4

GABA-B

Question 5

Tizanidine is an _____ receptor agonist

Answer 5

Alpha2

Question 6

Succinylcholine and Rocuronium are structurally similar to ACh, so they can bind to the post-synaptic ACh receptors. Which is a depolarizing blocker that causes vesiculation and which is a non-depolarizing blocker? Which has longer action?

Answer 6

Succinylcholine is a depolarizing blocker that causes vesiculation; Rocuronium is a non-depolarizing blocker.

Rocuronium has longer action, about 45mins vs 10mins for Succinylcholine

Question 7

_______ is the treatment for malignant hyperthermia. It is a ________ receptor antagonist that decreases Ca++ from the SR.

Answer 7

Dantrolene

Ryanodine receptor antagonist