Lecture 19 Male Repro Flashcards
Define: Spermatogenesis
Formation & maturation of spermatozoa
What is this? And what occurs here
Testis spermatogenesis
What are these arrows?
Blue: Stroma CT between cells
Yellow: Parenchyma – coiled seminiferous tubules
What cell types are the blue arrows and what do they secrete
Fenestrated capillaries & Leydig cells
testosterone
Leydig cells have acidophilic cytoplasm – lots of: Smooth ER
Vesicular mitochondria
Lipid droplets
Two parts of seminiferous tubule:
Two Cell Types in Seminiferous epithelium
Two cell types:
(1) Sertoli cell BLUE
(2) Spermatogenic cell RED
What cell Type is this?
Sertoli (sustentacular) cell
Secretes androgen-binding protein – concentrates testosterone in lumen
Look for large euchromatic nucleus w/ nucleolus
Four Cell Types
High to low
Spermatogonium is considered a ___ Cell
Stem cell
Look for cell on basement membrane
What cell type is this?
Spermatocyte undergoes meiosis
Look for large cell with patchy nucleus
What cell Types are these
BLUE: Near lumen each haploid spermatid starts as cell with round, pale nucleus
RED: Spermiogenesis = spermatid remodels into sperm Acrosome – enzymes to penetrate ovum
Condensed nucleus
Flagellum – motility (outside testes)
Define Acrosome
enzymes to penetrate ovum
What cell Type is this and its functionality
Sperm in lumen of seminiferous tubules are functionally immature
Cannot fertilize ovum yet
Not motile yet
What is this
Sertoli cells form blood-testis barrier
What is the purpose of the blood-testis barrier
Spermatogenesis needs an isolated & safe environment
One of the factors leading to male infertility is dysfunction of the blood- testis barrier. Exposure to blood may elicit immune responses against spermatocytes, spermatids, and sperm.
Tight junctions between Sertoli cells
- Epididymis
- Ductus deferens
- Ductus deferens
- Ejaculatory duct
- Prostatic urethra
- Penile urethra
What cell Type is this
Epididymis is a highly coiled duct
Epithelium secretes factors that:
1. Make sperm motile (functional flagella)
2. Inhibit premature fertilization by sperm (decapacitate)
What is this and what type of epithelium
Ductus deferens & rapid peristalsis
Short pseudostrat. epithelium w/ few stereocilia
What is this?
Seminal vesicle has one coiled tubule – many circular profiles
But pseudostratified epithelial lining of each circular profile is highly folded & branched (arrows)
What Cell type is this?
Prostatic
