lecture 17 Flashcards
1
Q
peptidooglycan cell wall of bacteria is different to eukaryotic cells
A
aim to find compounds that will kill bacteria and not the host, b-lactose
2
Q
antimicrobials come from natural fermentation
A
but is now cheaper to synthesise them from de novo
3
Q
DRUG LAUNCHING PROCESS
A
- show that compound doesn’t kill people (test on animals)
- Then in humans (students or poor people)
- Then efficacy test on humans, testing drug on people who are ill with the target disease
- then u get clinical trial certification
- early clinical trials
6 the controlled clinical trials - committee on safety of medicines- product licence
- Launch
4
Q
how long is patent period
A
12
5
Q
How long will it take you to make a profit on antibiotics??
A
23 years .
6
Q
death of the blockbuster
A
- saturated market
- GP’s conservative about what they prescribe bc of resistance
- increasing level of generic competition
- generics are made at extremely cheap prices in India but with NO regulation or environmental controls.
- generic manufacturer doesn’t have to synthesise or research so costs less
- acute timeframe
7
Q
anti-infectives
A
grown significantly less than all other segments mainly due to lack of launches genericisation and pricing pressure
8
Q
Net Present Value
A
describes relation between potential costs and potential cash flow
