Lecture 16: Tricyclic Antidepressant Poisoning Flashcards
1
Q
3 mechanisms of TCA poisoning
A
- Blockade of neuronal monoamine reuptake
- antimuscurinic activity
- Membrane stabilising effect on cardiac muscle
2
Q
How is blockade of neuronal monoamine reuptake caused by TCA poisoning
A
neurotransmitter released into synaptic cleft and reuptake blocked by TCA
3
Q
How is the antimuscurinic activity caused by TCA poisoning
A
TCA blocks muscurinic effects of acetylcholine
4
Q
How membrane stabilising effect on cardiac muscle caused by TCA poisoning
A
blockage of sodium channels
5
Q
What is the feature of mild to moderate TCA poisoning
A
peripheral antimuscurinic effects
6
Q
What are the 3 C’s of TCA poisoning
A
- Coma
- Convulsions
- Cardiac arrhythmia
7
Q
What are the 3 C’s of TCA poisoning
A
- Coma
- Convulsions
- Cardiac arrhythmia
8
Q
What is the symptomatic and supportive care for TCA poisoning
A
- ABC
- Management of convulsions
- Management of Delirium
9
Q
What is the management of arrhythmia cause by TCA poisoning
A
- correction of metabolic and respiratory acidosis by mechanical ventilator
- sodium bicarbonate
