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IDM2003 Exam 2 > Lecture 16 T cell mediated immunity > Flashcards

Lecture 16 T cell mediated immunity Flashcards

1
Q

3 development of the immune response

A
  1. nonspecific
  2. Central (priming) phase
  3. T cell effector phase
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2
Q

types of professional antigen cells

A

Dendritic cells
macrophages
B cells

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3
Q

Which cells prime naive T cells

A

dendritic cells

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4
Q

TFH express _____ and help B cells

A

CXCR5

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5
Q

What is signal 3?

A

delivery of cytokines from DC to T cell. Drives differentiation into functional effector role;
match effector response to the specific problem

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6
Q

what are the main function of TH1 cells

A

activate macrophages, provide help with antibody production. They target microbes in intracellular vesicles and extracellular bacteria

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7
Q

What is the main function of TH2

A

they help B cells class switch to IgE. Target helminth parasites

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8
Q

What is main function of TH17

A
  • get rid of fungal infections
  • maintaining gut epithelial barrier
  • enhance neutrophil response
  • promote barrier integrity (homeostastis)
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9
Q

CTL kills ____

A

virus infected cells (and cancer)

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10
Q

TFH main function

A

target all kinds of pathogens
help B cells with antibody production, isotype switching

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11
Q

CD4 regulatory cells function to

A

suppress T cell response

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12
Q

Which cytokinesspecify TH1 through T-bet?

A

IFN-gamma and IL-12 through STAT 1 and STAT4

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13
Q

what cytokines specify TH2 though GATA-3?

A

IL4 through STAT6

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14
Q

which cytokines specify TH17 through RORgammaT?

A

TGFbeta, IL23, IL6 though STAT3

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15
Q

Which cytokines specify TFH through Bcl-6?

A

IL6, TGF-beta, IL-21 through STAT3

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16
Q

Which cytokines specify Treg through FoxP3?

A

IL2, TGF-beta, IL10 through STAT5

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17
Q

what cytokines do TH1 cells make

A

IFN-gamma

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18
Q

what cytokines do TH2 cells make

A

IL4, IL5, IL13

19
Q

What cytokines do TH17 cells make

A

IL17, Il22

20
Q

What cytokines do TFH cells make?

A

IL21

21
Q

What cytokines do iTreg cells make

A

TGF-beta, IL10

22
Q

IFN-gamma and CD40L produced by ____ drive fusion of intracellular compartments in ______

A

TH1; macrophages

23
Q

IL4 activates _____, IL5 activates _______, IL13 helps to enhance barrier mucosal immunity, all produced by ___

A

mast cells and basoophils;
eosinphils;
TH2

24
Q

IL17 affects ____ cells and IL22 affects ____ cells with which will activate them to recruit _______ to the site of infection. The production of these cytokines is mediated by _____.

A

stromal cells;
epithelial cells;
neutrophils;
TH17

25
Q

____ produce Il21 that targets B cells and promotes expression of ______ to determine the B cell thats made

A

TFH; CXCR5

26
Q

____ cells inhibit DCs though expression of IL10, TGF-beta, and IL35

A

Treg

27
Q

Leishmaniasis is caused by _____ that infect macrophages and dendritic cells. Using susceptible/resistance mice strains and watching the response shows the T cell response that determines resistance. ___ is shown to play a role

A

sand fly protozoans. TH17

28
Q

BALB/c mice are ______ to Leishmania major because they generate ____ mediated ____ response.

A

susceptible, IL4, TH2

29
Q

C57/Bl6 are _____ because they generate ______ mediated ____ response

A

resistant; IFN-gamma; TH2

30
Q

BALB/c mice treated with ______, that reverses ____ response

A

an antibody that blocks IL-4;
TH2/Th1

31
Q

Mycobacterium leprae has a _______ leprosy with TH1 and _______ leprosy with TH2 responses

A

Th1, Th2

32
Q

IL4 secreted by ___ can inhibit differentiation of _____ cells because they block ____ receptor. Downregulation of STAT4 mediated signaling of this cytokine also decreases ___ production, inhibiting production of ______

A

TH2,
TH1, IL12,
IL23, Th17

33
Q

IFN-gamma produced by ___ cells leads to downregulation of ____ and the inhibition of ___ cells and downregulation of ____

A

TH1, IL4rec, TH2, IgE rec

33
Q
A
33
Q

Treg cells can inhibit the production of ___ and ___ cells through the release of TGF-beta

A

Th1 and TH2

34
Q

effector functions of Th1 cells are

A
  • IFN-gamma and CD40 ligand
  • Fas ligand or LTbeta
  • IL2
  • IL3 + GM-CSF
  • TNF-alpha +LTalpha
  • CXCL2
35
Q

What does Fas ligand or LTbeta do

A

kills chronically infected cells, releasing bacteria to be destroyed by other macrophages

36
Q

What does IL-2 do?

A
  • induce T cell proliferation
  • NK cells CTL
37
Q

What does IL3 +GM-CSF do?

A

induce macrophage differentiation in bone marrow

38
Q

What does TN-alpha + LT alpha do?

A

activate endothelium

39
Q

What does CXCL2 do?

A

attracts macrophages to site of infection

40
Q

IL2 produced by ___ activate ___ and ____

A

CD4+ T cells
CD8+ T cells and NK cells

41
Q

CD4+ cells can provide feedback signals to DCs though ____ and _____ leading to release of ___ or ____

A

IFN-gamma and CD40 L
IL10 or IL12

42
Q

Effector cells can respond to target cells ______ stimulation

A

without

IDM2003 Exam 2 (7 decks)

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