Lecture 16 (9a) - Neurogenesis in Drosophila and Vertebrates

Question 1

Neural progenitors are stem cells

Answer 1

• Drosophila

* vertebrates

Question 2

Nervous system is formed from single-layer neuroepithelium

Answer 2

• Drosophila

* vertebrates

Question 3

Neuroepithelium forms exclusively neural cells

Answer 3

• vertebrates

Question 4

Neuroepithelium forms neural and epidermal cells

Answer 4

• Drosophila

Question 5

Homologous genes specify neural stem cells

Answer 5

• Drosophila

* vertebrates

Question 6

Members of the achaete-scute family are the predominant proneural genes in the CNS

Answer 6

• Drosophila

Question 7

Notch signaling restricts the number of neural cells formed

Answer 7

• Drosophila

* vertebrates

Question 8

Notch signaling is used for binary decision between epidermal and neural fate

Answer 8

• Drosophila

Question 9

Notch and Delta are transmembrane proteins

Answer 9

• Drosophila

* vertebrates

Question 10

Notch is the receptor, Delta is the inhibitory ligand

Answer 10

• Drosophila

* vertebrates

Question 11

Proneural genes upregulate Delta transcription

Answer 11

• Drosophila

* vertebrates

Question 12

Binding of Delta to Notch activates Notch signaling

Answer 12

• Drosophila

* vertebrates

Question 13

The Notch receptor is cleaved and the intracellular domain enters the nucleus

Answer 13

• Drosophila

* vertebrates

Question 14

The Notch intracellular domain binds to Su(H) in the nucleus and activates E(sp)/Hes genes

Answer 14

• Drosophila

* vertebrates

Question 15

E(sp)/Hes genes inhibit proneural gene expression

Answer 15

• Drosophila

* vertebrates

Question 16

Notch signaling maintains the neural stem cell pool (comparison ventral nerve cord Drosophila/CNS vertebrates)

Answer 16

• vertebrates

Question 17

Proneural genes are required for the formation of neural stem cells

Answer 17

• Drosophila

* vertebrates

Question 18

Proneural genes promote cell cycle exit

Answer 18

• vertebrates

Question 19

Proneural genes are required for delamination

Answer 19

• Drosophila

* vertebrates

Question 20

Proneural genes are required for migration

Answer 20

• vertebrates

Question 21

Dorso-ventral patterning genes are involved in neural stem cell subtype identity

Answer 21

• Drosophila

* vertebrates

Question 22

Subtype identity is acquired during migration to final destination

Answer 22

• vertebrates

Question 23

The neurogenic genes are members of the Notch signaling pathway

Answer 23

• Drosophila

* vertebrates

Question 24

Achaete-scute/atonal proteins are transciption factors

Answer 24

• Drosophila

* vertebrates

Question 25

Proneural genes promote the formation of neurons

Answer 25

• vertebrates

Question 26

Proneural genes suppress the formation of glial cells

Answer 26

• vertebrates

Question 27

Hb, kr, pdm, and castor are required for temporal diversity (neural diversity)

Answer 27

• Drosophila

Question 28

Notch signaling is required for temporal identity (eg neurons are generated before glial cells)

Answer 28

• vertebrates

Question 29

The neural cell fate determinant Numb is asymmetrically distributed during division of the neural stem cell

Answer 29

• Drosophila

* vertebrates

Question 30

BMP and hedgehog determine dorso/ventral fate in a concentration dependent manner

Answer 30

• vertebrates

Question 31

Several types of neural stems cells in brain

Answer 31

• Drosophila

* vertebrates

Question 32

Notch signaling maintains neural stem cell pool in brain

Answer 32

• Drosophila

* vertebrates

Question 33

Achaete-scute/atonal proteins form heterodimers with daughterless/E-proteins

Answer 33

• Drosophila

* vertebrates

Question 34

Members of the atonal family are the predominant proneural genes in the CNS

Answer 34

• vertebrates