Lecture 14 3/13/14 Flashcards
Hormonal Regulation of Blood Pressure - 4 Parts
ADH
Renin-Angiotensin-Aldosterone System
Erythropoetin
ANH
ADH
Antidiuretic Hormone
Produced by the supraoptic nuclei of the hypothalamus. Also known as vasopressin. ADH is released and it tells the collecting ducts of the kidneys to retain water. Produced in response due to decrease in blood volume or increase in osmolarity or electrolyte concentration.
ADH Functions Two Ways
Stimulates kidneys to retain H2O, preventing loss in blood volume
Stimulates Vasoconstriction of peripheral vessels to increase blood pressure. Vasopressin is another word for increasing blood pressure
Renin Angiotensin Aldosterone System
Increase blood pressure
Starts out because of decreased blood flow to kidneys, so then renin is released from the Kidneys and in conjunction with Angiotensinogen made by the liver and together It creates Angiotensinogen I which is a mild vasoconstrictor, which goes to the lungs and exposed to ACE and it converts Angiotensinogen I to Angiotensinogen II. Angio II is a powerful vasoconstrictor. It then increases aldosterone, increases thirst drive, which helps increase fluid volume, ADH, and vasoconstriction. To ultimately increase blood pressure.
Aldosterone
Mineralcorticoid, retain salt, which retains water.
Erythropoetin
released from the kidneys, has it effects on bone marrow, to increase red blood cell production. Helps increase hematocrit.
Also released when Blood pressure falls or O2 concentrations decrease.
Results in increased RBC’s, increased O2 carrying capacity
Atrial Natriuretic Hormone/Peptide
Hormone produced by specialized cells in the Right Atrium, that when stretched, causes ANH to be produced, causing excretion of Sodium, with that, goes water. decreases blood pressure. Only hormone that decreases blood volume or pressure. Because historically we had no access to water.
Hematocrit
PCV - Pack Cell Volume
Why does ANH get released?
Because when BP increases too much. Which leads to increase water loss in kidneys, decreases thirst and blocks ADH and Aldosterone
Pulmonary Circulation
Functions to oxygenate blood
Pathway - unoxygenated blood leaves pulmonary artery from the right ventricle and travels to the lungs to be oxygenated. Oxygenated blood returns to the Left Atrium.
Systemic Circulation
Pathway - take that oxygen blood and send it out to the peripheral tissues and return unoxygenated blood to the heart.
Arteries of the Systemic Circulation
Ascending Aorta
Aortic Arch
Vertebral Arteries
Common Carotids
Ascending Aorta
Largest artery, first to exit heart,
First branches are the coronary arteries off of the ascending aorta.
Aortic Arch
3 Main branches
Brachiocephalic Trunk
Left Common Carotid
Left Subclavian
Brachiocephalic
First branch supplies right arm and head.
Right Common Carotid
Right Head and Neck
Right Subclavian
Right upper extremity and right upper thorax.
Left Common Carotid
2nd branch supplies left side of head
Left Subclavian
3rd main branch supplies left upper extremity and left thorax.
Vertebral Arteries
Both right and left vertebral arteries arise off of the subclavian of their respective sides and travel up through the transverse foramen of the cervical vertebrae to enter the skull through foramen magnum. They come together to form the basilar artery
Common Carotids
Travel up just lateral to trachea and deep to the sternocleidomastoid mandible and split into an internal and external carotid artery. At the level of the hyoid bone.
External Carotid
Supplies the head outside the skull
4 Main Branches
Lingual
Facial
Maxillary
Temporal
Lingual
1st branch supplies floor of mandible, goes to the tongue
Facial
2nd branch supplies face, travels under the mandible just anterior to the angle of jaw. Continues up medially toward the medial angle of the eye.
Tortuous for jaw movement, opening and closing, stretching
Maxillary
3rd branch Supplies maxillary region
Temporal
4th branch, but terminal, supplies scalp and external jaw muscles. Pulse can be taken here
Internal Carotid
Supplies brain and tissues inside skull. Enters skull through carotid canal
Circle of Willis
Blood supply to the brain.
Circular blood supply within the skull that allows for collateral blood supply to the brain.
Considered an anastomosis - a connection between blood vessels that acts as a safety mechanism to ensure a continuous blood supply should a vessel become blocked. It has 2 vertebrals and 2 carotids
Arteries of the Upper Extremity
Subclavian (bilateral) -> Axillary (travels through axilla) ->Brachial (travels through arm on medial side, pulse point - brachial pulse
Brachial Splits into
Radial - travels down lateral forearm (radial pulse)
Ulnar - travels down medial forearm
Arteries of the Thorax and Abdominal Cavity
Aortic Arch -> Thoracic Arch -> Abdominal Aorta