Lecture 13 - Principles of Cell Communication Flashcards
In multicellular organisms, cells must communicate to
Organise themselves into a functioning unit
Cells sending signals must be able to
Control the signals
Cells receiving signals must be able to
Interpret the information accurately
Communication is mediated by
Extracellular signalling molecules
Signalling molecules can
Interact with receptor molecules in the plasma membrane
The receptors in the plasma membrane
Transmit the signal inside the cell to activate a signalling cascade
What can a signalling cascade do? (4)
Changes enzymatic activity
Metabolism
Gene expression
Induce rearrangements of the cytoskeleton (movement etc.)
Signal transduction
When the signal is transmitted into a cell
Effector molecules alter the
Behaviour of the cell in response to a signal
Examples of signalling molecules
Nucleotides (cAMP, NADPH) Adrenalin (small molecules) Oestrogen (steroids) Insulin (proteins and peptides) Mal-CoA (fatty acids) Nitirc oxide (dissolved gases
Nitric oxide
Is used as a signal to relax smooth muscle in blood vessels
Increases blood flow
How viagra works
Inhibits phosphodiesterase Type 5 from degrading cGMP
NO signalling
- NO synthase upregulated
- Smooth muscle cells activate Guanylyl Cyclase
- Guanylyl cyclase produces more cGMP
- Blood flow is increased as vessels relax
Extracellular signals can act over
Long or short distances
Cell signalling is mediated by
Contacts with the target cell