Lecture 13 - Principles of Cell Communication Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

In multicellular organisms, cells must communicate to

A

Organise themselves into a functioning unit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cells sending signals must be able to

A

Control the signals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cells receiving signals must be able to

A

Interpret the information accurately

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Communication is mediated by

A

Extracellular signalling molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Signalling molecules can

A

Interact with receptor molecules in the plasma membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The receptors in the plasma membrane

A

Transmit the signal inside the cell to activate a signalling cascade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What can a signalling cascade do? (4)

A

Changes enzymatic activity
Metabolism
Gene expression
Induce rearrangements of the cytoskeleton (movement etc.)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Signal transduction

A

When the signal is transmitted into a cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Effector molecules alter the

A

Behaviour of the cell in response to a signal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Examples of signalling molecules

A
Nucleotides (cAMP, NADPH)
Adrenalin (small molecules)
Oestrogen (steroids)
Insulin (proteins and peptides)
Mal-CoA (fatty acids)
Nitirc oxide (dissolved gases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Nitric oxide

A

Is used as a signal to relax smooth muscle in blood vessels

Increases blood flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How viagra works

A

Inhibits phosphodiesterase Type 5 from degrading cGMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

NO signalling

A
  1. NO synthase upregulated
  2. Smooth muscle cells activate Guanylyl Cyclase
  3. Guanylyl cyclase produces more cGMP
  4. Blood flow is increased as vessels relax
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Extracellular signals can act over

A

Long or short distances

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cell signalling is mediated by

A

Contacts with the target cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The 5 ways of getting a signal to the right place

A
  1. Contact dependent
  2. Paracrine
  3. Synaptic
  4. Endocrine
  5. Gap junctions
17
Q

Contact dependent cell signalling

A

Via membrane bound receptors and membrane bound signalling molecules

Important in immune response and development
Involved in determining cell fate

18
Q

Paracrine cell signalling

A

Release of signalling molecules into the extracellular fluid

Acts locally only
Rapidly taken up and sequestered/destroyed by neighbouring cells

19
Q

Synaptic cell signalling

A

Chemical secreted across a space as a result of an electrical impulse

Short range (from perspective of cell-cell contact)
Long range (due to of length of cell)
Fast 
Specific
High concentrations
Low affinity
20
Q

Endocrine cell signalling

A

Long range signalling to distant cells

Hormones secreted into the bloodstream
Specific
Highly dilute
Low concentrations
High affinity
21
Q

Gap junction cell signalling

A

Direct communication between neighbouring cells

Narrow cytoplasmic filled channels
Exchange of ions and small molecules (Ca2+, cAMP)
Directionality of signal (not all cells have GJ)

22
Q

Connexins

A

6 subunit protein that forms GAP junctions (small channels in cell membranes)
Twist open or closed

23
Q

Gap junctions are important in cell signalling in

A
The heart (Ca2+)
The bones (cells surrounded by bone supplied by nutrients by GJ)
24
Q

Extracellular signals are communicated inside the cell by (2)

A
  1. Directly - signal passes into cell (steroids, GJ)

2. Indirectly - binds a receptor, induces conformational change

25
Q

Signalling inside the cell: Ion channel coupled (indirect)

A

Rapid synaptic signalling
Muscle cells
Gated channels (conformational change as charged residues are removed, allowing ion influx)

26
Q

Signalling inside the cell: G protein coupled (GPCRs)

A

Receptors have 7 transmembrane domains (serpentine)
Ligand binds, complexes with trimeric G proteins (alpha beta gamma subunits)
Activate an enzyme at the plasma membrane
Transmits a signal
e.g generation of cAMP by adenylyl cyclase

27
Q

40% of modern drugs target

A

G protein coupled receptors

28
Q

Signalling inside the cell: Enzyme coupled receptors

A

Transmembrane proteins, either an enzyme or directly bound to it (dimerises or form complexes)
Most common are Receptor Tyrosine Kinases
Autophosphorylation causes docking sites for downstream receptors

29
Q

When Receptor Tyrosine Kinases bind a signalling molecule they form

A

Dimers in the membrane
Activates phosphorylation domains in the cytosol
Beginning of signal transduction cascade