Lecture 12 Humane endpoints Flashcards
1
Q
Definition of HEP
A
To define a set of intervention points which allows the collection of quality scientific data
but limits the amount of suffering for the animal
2
Q
Weight loss
A
20% weight loss of normal weight during study, or 15% weight loss within 2 days.
3
Q
Body temperature
A
drop in body temp >4oC
4
Q
tumour volumes
A
o Mouse max 1.2x1.2 cm
o Rat max 2.5x2.5 cm
5
Q
Ascites
A
> 10% of body weight
6
Q
Diarrhoea/incontinence
A
> 48 hours
