Lecture 12 - Gluconeogenesis

Question 1

Three sources of blood glucose are:

Answer 1

1. Glycerol
2. Lactate
3. Glucogenic amino acids

Question 2

Lactate can be extracted by the liver and used for gluconeogenesis. The key enzymes in this cycle are ________ that work in opposite directions in the liver and the anaerobic tissues.

Answer 2

lactate dehydrogenase (LDH) isozymes

Question 3

The following reaction is catalyzed by ______.

pyruvate + CO2 + ATP + H2O –>
oxaloacetate + ADP +Pi

A. PEPCK
B. Pyruvate carboxylase
C. FBPase-1
D. G-6-Pase

Answer 3

B

Question 4

The following reaction is catalyzed by ______.

Oxaloacetate + GTP –>
Phosphoenolpyruvate + GDP + Pi + CO2

A. PEPCK
B. Pyruvate carboxylase
C. FBPase-1
D. G-6-Pase

Answer 4

A

Question 5

The following reaction is catalyzed by ______.

Fructose-1,6-P2 + H2O –> Fructose-6-P + Pi

A. PEPCK
B. Pyruvate carboxylase
C. FBPase-1
D. G-6-Pase

Answer 5

C

Question 6

The following reaction is catalyzed by ______.

Glucose-6-P + H2O –> Glucose + Pi

A. PEPCK
B. Pyruvate carboxylase
C. FBPase-1
D. G-6-Pase

Answer 6

D

Question 7

What allosterically activates FBPase-1?

Answer 7

ATP

Question 8

What allosterically inhibits FBPase-1?

Answer 8

AMP, F-2,6-P2 (liver)

Question 9

Where is G-6-Pase found?

Answer 9

endoplasmic reticulum

Question 10

Where is PEPCK located?

Answer 10

cytosol