Lecture 12 Flashcards

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1
Q

chromosomal duplications are

A

repeated segment of chromosome

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2
Q

how do duplications arise

A

through replication error prior to meiosis

through unequal crossing over between synapsed chromosomes during meiosis

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3
Q

what are three results from duplications?

A

gene redundancy
phenotypic variation
source of genetic variability during evolution

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4
Q

redundancy is

A

ribosomal RNA

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5
Q

redundancy

A

multiple copies of genes code for rRNA

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6
Q

is a single copy sufficient in redundancy?

A

no

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7
Q

DNA that codes for rRNA is called

A

rDNA

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8
Q

what is essential in abundance in a cell to support protein synthesis

A

gene product

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9
Q

how do new genes arise?

A

non-functionalization
neo-functionalization
sub-functionalization

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10
Q

inversions are

A

rearrangement of linear gene sequence

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11
Q

during inversions the segment of a chromosome turns how far within a chromosome

A

180 degrees

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12
Q

is there a loss of genetic information in inversions

A

no

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13
Q

how many breaks do inversions require

A

2

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14
Q

when does the chromosomal loop form

A

prior to breakage

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15
Q

what do inversions create to close together and rejoin

A

sticky ends

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16
Q

what may the inverted segment not include

A

centromere

17
Q

paracentric inverision

A

does not include centromere

18
Q

pericentric inversion

A

includes the centromere

19
Q

when does linear (normal) synapse not occur

A

it is not possible if only one member of homologous pair has inverted segment

20
Q

inversion heterozygotes are

A

organisms with one inverted chromosome and one non-inverted homolog

21
Q

pairing between inversion heterozygotes require an

A

inversion loop

22
Q

how many recombinants does a crossover of paracentric inversions produce

A

two- dicentric and acentric

23
Q

dicentric chromatid

A

two centromeres

24
Q

acentric chromatid

A

lacking a centromere

25
Q

translocation is the…

A

movement of chromosomal segment to new location in genome

26
Q

reciprocal translocation is

A

exchange of segments between non-homologous chromosomes

genetic information not lost or gained just rearranged

does not directly alter viability of individual

27
Q

homologs that are heterozygous for reciprocal translocation undergo…

A

unorthodox synapsis during meiosis

28
Q

what are two possible segregation patterns

A

alternate segregation leads to normal and balanced gametes

adjacent segregation leads to gametes containing duplications and deficiencies.

29
Q

alternate segregation leads to

A

normal and balanced gametes

30
Q

adjacent segregation leads to

A

gametes containing duplications and deficiencies