Lecture 12

Question 1

Are hairy ears Y linked

Answer 1

No

Question 2

Hemophilia A is a defect in

Answer 2

Clotting factor VIII

Question 3

Hemophilia B is a defect in

Answer 3

Clotting factor IX

Question 4

Hemophilia A and B are ____ disorders

Answer 4

X linked recessive

Question 5

Hemophilia C is caused by defect in

Answer 5

Clotting factor XI

Question 6

Which chromosome is hemophilia C found

Answer 6

Chromosome 4
Autosomal recessive

Question 7

In X-linked diseases, mostly ____ are affected

Answer 7

Males

Question 8

Why are Y linked genes not common

Answer 8

Y chromosome is smaller than X with fewer genes

Question 9

Pseudoautosomal inheritance

Answer 9

Very few genes found on both X and Y chromosomes

Question 10

Psuedoautosomal inheritance is found on what regions

Answer 10

Homologous

Question 11

Polymorphisms

Answer 11

Common variations in DNA

Question 12

Molecular marker

Answer 12

DNA variation that is found at a specific site in a genome

Question 13

Examples of molecular markers

Answer 13

SNPs - single nucleotide morphonisms
SSLP - Simple sequence length polymorphisms
Microsatellite (short tandem repeats)

Question 14

What does it mean if the markers are always inherited with the mutant phenotype

Answer 14

It means the molecular marker and gene is linked

Question 15

All RFLPs (Restriction fragment length polymorphism) are

Answer 15

SNPs

Question 16

No all SNPs are

Answer 16

RFLPs

Question 17

Southern blotting

Answer 17

Finding specific nucleic acids using DNA hybridization

Question 18

Probe

Answer 18

Small piece of DNA which has a sequence that is complementary to a sequence

Question 19

Heterozygous have how many bands

Answer 19

3

Question 20

Smaller DNA fragments move

Answer 20

Farther/faster

Question 21

MIcrosatellites

Answer 21

Short, repetitive sequences

Question 22

SNP can have how many alleles

Answer 22

4

Question 22

Amplified region in a microsattelite is called

Answer 22

Sequence tagged site

Question 23

Diploid cells have how many copies of STS

Answer 23

2

Question 24

If both homologous chromosomes carry the same number of repeats there is a

Answer 24

Single band on gel

Question 25

If 2 homologs each carry different number of repeats its

Answer 25

Two bands on gel

Question 26

Haplotype

Answer 26

Linkage of multiple different alleles on a single stretch of chromosome

Question 27

Crossing over is unlikely between

Answer 27

Closely linked loci

Question 28

The closer a molecular marker is to a disease gene, the greater the

Answer 28

Association and linkage

Question 29

Alleles are _____ NOT ______

Answer 29

Short tandem repeats, NOT SNPs (single nucleotide morphism)

Question 30

Amelogenin

Answer 30

Protein involved in the development of enamel
located on X and Y chromosome