Lecture 12 Flashcards
(32 cards)
Are hairy ears Y linked
No
Hemophilia A is a defect in
Clotting factor VIII
Hemophilia B is a defect in
Clotting factor IX
Hemophilia A and B are ____ disorders
X linked recessive
Hemophilia C is caused by defect in
Clotting factor XI
Which chromosome is hemophilia C found
Chromosome 4
Autosomal recessive
In X-linked diseases, mostly ____ are affected
Males
Why are Y linked genes not common
Y chromosome is smaller than X with fewer genes
Pseudoautosomal inheritance
Very few genes found on both X and Y chromosomes
Psuedoautosomal inheritance is found on what regions
Homologous
Polymorphisms
Common variations in DNA
Molecular marker
DNA variation that is found at a specific site in a genome
Examples of molecular markers
SNPs - single nucleotide morphonisms
SSLP - Simple sequence length polymorphisms
Microsatellite (short tandem repeats)
What does it mean if the markers are always inherited with the mutant phenotype
It means the molecular marker and gene is linked
All RFLPs (Restriction fragment length polymorphism) are
SNPs
No all SNPs are
RFLPs
Southern blotting
Finding specific nucleic acids using DNA hybridization
Probe
Small piece of DNA which has a sequence that is complementary to a sequence
Heterozygous have how many bands
3
Smaller DNA fragments move
Farther/faster
MIcrosatellites
Short, repetitive sequences
SNP can have how many alleles
4
Amplified region in a microsattelite is called
Sequence tagged site
Diploid cells have how many copies of STS
2