Lecture 11 : TCA Cycle

Question 1

Critical glycolysis enzyme reactions

Answer 1

Question 2

Gluconeogenesis note

Answer 2

To go from pyruvate to glucose, it uses (top right)

Question 3

What is the TCA Cycle

Answer 3

• Takes place in matrix of mitochondria
• Only occurs if O2 is present

Question 4

Pyruvate Dehydrogenase

Answer 4

• Pyruvate enters mitochondria and pyruvate dehydrogenase (3 enzyme complex)
• Catalyses IRREVERSIBLE oxidative decarboxylation of pyruvate into acetyl CoA, CO2 and NADH
• This bit generates 2 NADH from each pyruvate

Question 5

The cycle i actually need to know

Answer 5

Find a worded desription of this

Question 6

How does the ETC work

Answer 6

fibd

Question 7

What is an uncoupling protein

Answer 7

• Channel protein in inner mitochondrial membrane
• Allows protons to cross intter mitochondrial membrane without generating ATP
• Generates heat though

Question 8

In times of plenty…

Answer 8

ATP, NADH, acetyl-CoA and citrate accumulate, need to be regulated, reversible reactions from earlier may occur to reduce conc of molecules

• more glycogen produced,
• acetyl can be drawn from central pathway to synthesise fatty acids

Question 9

What is acetyl polymerisation

Answer 9

Question 10

Fat metabolism

Answer 10

Question 11

What is beta oxidation

Answer 11

Question 12

more

Answer 12

Question 13

Protein metabolism

Answer 13

Nitrogen -> Ammonia -> urea -> excreted

Question 14

Know urea cycle, where proteins adn fats come in