Lecture 10 - haemotology III Flashcards
What is the alternate name for white blood cells
Leukocytes
Granulocytes (% of WBCs)
Neutrophils (60-70%), eosinophils (2-4%), and basophils (<1%)
Agranulocytes (% of WBCs)
Lymphocytes (20-30%), monocytes (2-8%)
The ratio of RBC:WBC:Platelets
700:40:1
Neutrophils: what % of total WBCs do they make up, what is their structure, and what is their function?
50-70%
9-15 microns in diameter, a distinctive nucleus with 2-5 lobes, with granular cytoplasm
The first line of defence as a phagocytic, mobile leukocyte, circulates in the blood for ~10 hours, the main component of pus
Eosinophils: what % of total WBCs do they make up, what is their structure, and what is their function?
2-4%
10-12 microns in diameter with a bilobular nucleus
Combat parasites, circulate in the blood for ~8-12 hours before they migrate to tissues where they survive for 1-3 days, a main component of pus
Basophils: what % of total WBCs do they make up, what is their structure, and what is their function?
<1%
8-10 microns in diameter, bilobed “S” shape nucleus with large cytoplasmic granules (containing histamine and heparin)
Inflammatory response, unknown lifespan, share a common bone marrow precursor to mast cells
Monocytes: what % of total WBCs do they make up, what is their structure, and what is their function?
2-10%
up to 20 microns in diameter, a large kidney-shaped nucleus with extensive cytoplasmic
Migrate out of circulation after 3-4 days, act as macrophages in tissues for several months
Lymphocytes: what % of total WBCs do they make up, what is their structure, and what is their function?
20-30%
6-15 microns in diameter
A central role in all immune responses, moves throughout the tissues using lymph nodes and blood plasma, lifespan of weeks to several years
Types of lymphocytes
t cells - supply b cells with the antigens of pathogen
b cells - differentiate into plasma cells that destroy a specific pathogen by secreting antibodies
NK cells - “immune surveillance” (preventing cancer)
