Lecture 10

Question 1

Protein Folding Accessory Proteins

Answer 1

• Not all proteins can fold by themselves
• Help folding proteins quickly reach their native state
• Folding information still in primary sequence of the protein

Question 2

1-Protein Disulphide Isomerases (PDI)

Answer 2

Catalyze thiol-disulphide exchange so that correct disulphides will form in a folding protein and incorrectly formed ones will be rearranged to the correct ones

Question 3

2-Peptidyl Prolyl Cis-Trans Isomerases

Answer 3

• These enzymes increase the rate of the interconversion of cis and trans peptide bonds at proline residues
• peptide bond usually in trans configuration