Lecture 10

Question 1

Subthalamic nucleus

Answer 1

• Target for DBS
• Involved in parkinson’s disease, essential tremor, dystonia

Question 2

Subthalamic nucleus tripartite division

Answer 2

1. Motor
2. Associative
3. Limbic

Question 3

Immunocytochemical approache to study STN

Answer 3

Functional segregation: neuronal cell types move apart during development, depending on the specializations they acquire.

Question 4

Susceptibility for psychiatric disorders sex differences

Answer 4

• Women: Alzheimers, addiction, MDD, Anxiety, PTSD, eating disorders
• Men: ASS, ADHD, Schizophrenia

Question 5

Inclusion and exclusion criteria for in vivo studies

Answer 5

• On top of literature
• Safety of participants
• Ethical aspects
• Number of participants
• Feasibility

Question 6

Inclusion and exclusion criteria for post mortem studies

Answer 6

• On top of literature
• Ethical aspects
• Number of participants
• Feasibility

Question 7

Confounders post mortem studies

Answer 7

• Post mortem delay
• Brain weight
• pH of brain/CSF
• Cause of death
• Clock time of death
• Date of death
• Freezing/fixation
• Storage time

Question 8

What to stain for

Answer 8

• Myelin/axons: Myeloarchitecture
• Nissl: Cytoarchitecture
• Hematoxylin and eosin: pathology
• Calcium binding proteins: anatomical detail