Lecture 10/12

Question 1

Which nutrients were found to have a positive correlation with cognitive function in non-demented patients in the Alzheimer’s Study?

Answer 1

Blue nutrients have better cognitive outcomes
-Beta carotene
-Zeaxanthin
Red nutrients have negative correlation
-Trans fatty acids are bad

Question 2

What are the limitations to studying the relationship between nutrition and cognition?

Answer 2

You cannot assure that the lack of something causes dementia and you cannot assume that a lack of correlation in one singular study means that it is not true
—In the denmark study vitamin B12 and Folic Acid deficiency has no correlation with dementia

Question 3

What is your conclusion about the Danish study on cognition and diabetes?

Answer 3

There is no association based on the Danish study that demented and non demented patients within the diabetic group are equal
-A lot of emerging studies have found a mechanistic link between dementia and diabetes

Question 4

What is the advantage of constructing serum nutrient patterns (NP) as a marker of intake among subjects when studying the relationship between nutrition and cognitive health?

Answer 4

-Using SNP overcomes the recall bias especially for subjects with varied cognitive performances that some of them may have hard time recalling information
-Overcomes the issue of inter-individual variability in nutrient absorption and metabolism

Question 5

What is a common neuropathological indicator of Alzheimer’s disease?

Answer 5

Abnormal aggregates of AB in the form of senile plaques (SP) and abnormally phosphorylated tau in the form of neurofibrillary tangles (NFTs)