Lecture 1, Overview Flashcards
What CD marker(s) are granulocytes positive for?
CD15
What CD marker(s) are monocytes positive for?
CD14
What CD marker(s) are DCs positive for?
CD11c
What CD marker(s) are all T lymphocytes positive for?
CD3
What CD marker(s) are T helper lymphocytes positive for?
CD3, *CD4
What CD marker(s) are T cytotoxic lymphocytes positive for?
CD3, *CD8
What CD marker(s) are B lymphocytes positive for?
CD19
What CD marker(s) are natural killer cells positive for?
CD56
What proportion of each of the 5 major WBC classes are found in the blood, in order?
- Neutrophils (40-75%)
- Lymphocytes (20-50%)
- Monocytes (2-10%)
- Eosinophils (1-6%)
- Basophils (less than 1%)
Blood-born antigens are captured by APCs in the ________ (organ).
spleen
Antigens in epithelia and CT are collected in the ________ (area).
lymph nodes
Distinguish the different classes of MHC.
Class I is all nucleated cells and is A, B, C
- Self
Class II is DP, DQ, DR
- Non-self
Differentiate, generally, bacteria, fungi, and viruses.
Bacteria – microorganisms in the environment. Grow rapidly and compete with our cells for nutrients.
Fungi – organisms like mold and yeast. Invade tissues.
Viruses – proteins and nucleic acid. Take over cells and generate their own genetic instructions.
Define antigen.
Antibody generators: Molecules which stimulate production of and bind specifically to an AB and/or elicit an immune response
What generally happens during a humoral response?
ABs are produced by Ig-secreting B cells (plasma cells)
- Directed against cell associated and free floating antigens, i.e., bacteria, proteins, etc
What generally happens during a cell-mediated response?
Killing of cells by cytotoxic T lymphocytes (CTLs) and/or production of cytokines by other T cells
- Directed against infected/defective cells, non-self cells
During a humoral response, what 2 places would you find B cells? (Think I meant ABs)
In extracellular fluids (blood plasma, lymph, mucus, etc.) and *on the surface of B cells.
Difference b/w active and passive immunity?
- In active, you mount your own immune response (natural exposure or artificial injection of antigen).
- In passive, you borrow outside ABs (e.g. mother’s during birth, naturally, or giving serum ABs artificially)
4 types of immune disorders?
- Immune deficiency (genetic)
- HIV/AIDS
- Cancer (must be immuno-compromised)
- Autoimmune disorders
In the LN, where are the B cells primarily located?
Cortex/follicle
In the LN, where are ABs produced by B cells s/p Ag stimulation?
Germinal centers
In the LN, where are the T cells primarily located?
Paracortex
In the LN, where are most of the macrophages primarily located?
Medulla
