Chemokine Summary Flashcards by Dave Ed

Q

IFN-gamma: main cell source?

A

Th1, NK cells, NKT cells

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Q

IFN-gamma: major functions?

A

TMMI (T cell mediated macrophage immunity), inhibits Th17

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Q

IL-1: main cell source?

A

Monocytes/macrophages, other cells

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Q

IL-1: major functions?

A

Pro-inflammatory

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Q

IL-2: main cell source?

A

Th1

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Q

IL-2: major functions?

A

T cell proliferation, Treg survival

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Q

IL-4: main cell source?

A

Th2

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Q

IL-4: major functions?

A

AB immunity, inhibits Th17

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Q

IL-6: main cell source?

A

Monocytes/macrophages, other cells

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Q

IL-6: major functions?

A

Innate immunity, B cell growth, induction Th17

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Q

IL-8: main cell source?

A

Monocytes/macrophages, other cells

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Q

IL-8: major functions?

A

Pro-inflammatory, major neutrophil chemokine

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Q

IL-10: main cell source?

A

DCs, monocytes/macrophages, Th2, Tregs

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Q

IL-10: major functions?

A

Suppression of some inflammation pw’s

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Q

IL-12: main cell source?

A

Monocytes/macrophages, DCs

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Q

IL-12: major functions?

A

Induction of Th1

Q

IL-21: main cell source?

A

Th1, Th2, Th17

Q

IL-21: major functions?

A

Proliferation of Th1, Th2, Th17

Q

IL-23: main cell source?

A

Monocytes/macrophages, DCs

Q

IL-23: major functions?

A

Th17 expansion and stablization

Q

TNF-alpha: main cell source?

A

Monocytes/macrophages, DCs

Q

TNF-alpha: major functions?

A

Pro-inflammatory

Q

TGF-beta: main cell source?

A

Many cells

Q

TGF-beta: major functions?

A

Induction of Tregs or Th17