Lecture 1-Hormones That Regulate Feeding Behavior Flashcards

1
Q

Ghrelin-binds to what type of receptor?

A

Binds to growth hormone secretagogue receptors

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2
Q

Ghrelin-What does it do in the hypothalamus?

A

Stimulates neurons that release NPY

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3
Q

Ghrelin-other actions?

A
  • Increases appeptite, gastric motility, gastric acid secretion, adipogenesis
  • Initiates the feeding response
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4
Q

Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-Insulin-binds to what type of receptor?

A

Binds to receptors in satiety and hunger centers within the hypothalamus (POMC and NPY systems)
-Inhibits NPY and stimulates POMC pathway

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5
Q

Insulin-actions?

A

Decreases appetite and increases metabolism

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6
Q

Insulin-what happens in patients with diabetes mellitus type I?

A

In patients with diabetes mellitus type I, there is an increase in food intake associated with decreased insulin
-Explanation-If there is less insulin, the NPY pathway is being inhibited less causing increased food intake?

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7
Q

Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-CCK-released by?

A

I cells in the duodenum

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8
Q

CCK-actions?

A
  • Elicit satiety-acts on vagal->NTS->hypothalamus circuit
    • decreased ghrelin
  • Decreased gastric emptying and increased gastric distention
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9
Q

Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-PYY-released by?

A

Released by EECs (L cells) of the ileum and colon following a meal

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10
Q

PYY-binds to what receptors?

A

Binds to Y2 receptors of the hypothalamus

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11
Q

PYY-actions?

A
  • Inhibits NPY neurons and releases inhibition of POMC neurons
    • Decreased food intake-potential as an appetite suppressor
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12
Q

Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-Leptin-secreted by?

A

-Secreted by cells in adipose tissue and endocrine cells in the stomach

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13
Q

Leptin-binds to what type of receptor?

A

Binds to receptors in satiety and hunger centers within the hypothalamus (POMC and NPY systems)

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14
Q

Leptin-actions?

A
  • Inhibits NPY and stimulates POMC pathways
  • Appetite suppressing hormone
    • decreased ghrelin release and appetite
    • increased metabolism
  • Appears to be part of negative feedback system for the regulation of food intake
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15
Q

Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-Ghrelin-secreted by?

A

Endocrine cells in the stomach

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