Lecture 1-Hormones That Regulate Feeding Behavior Flashcards
Ghrelin-binds to what type of receptor?
Binds to growth hormone secretagogue receptors
Ghrelin-What does it do in the hypothalamus?
Stimulates neurons that release NPY
Ghrelin-other actions?
- Increases appeptite, gastric motility, gastric acid secretion, adipogenesis
- Initiates the feeding response
Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-Insulin-binds to what type of receptor?
Binds to receptors in satiety and hunger centers within the hypothalamus (POMC and NPY systems)
-Inhibits NPY and stimulates POMC pathway
Insulin-actions?
Decreases appetite and increases metabolism
Insulin-what happens in patients with diabetes mellitus type I?
In patients with diabetes mellitus type I, there is an increase in food intake associated with decreased insulin
-Explanation-If there is less insulin, the NPY pathway is being inhibited less causing increased food intake?
Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-CCK-released by?
I cells in the duodenum
CCK-actions?
-
Elicit satiety-acts on vagal->NTS->hypothalamus circuit
- decreased ghrelin
- Decreased gastric emptying and increased gastric distention
Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-PYY-released by?
Released by EECs (L cells) of the ileum and colon following a meal
PYY-binds to what receptors?
Binds to Y2 receptors of the hypothalamus
PYY-actions?
- Inhibits NPY neurons and releases inhibition of POMC neurons
- Decreased food intake-potential as an appetite suppressor
Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-Leptin-secreted by?
-Secreted by cells in adipose tissue and endocrine cells in the stomach
Leptin-binds to what type of receptor?
Binds to receptors in satiety and hunger centers within the hypothalamus (POMC and NPY systems)
Leptin-actions?
- Inhibits NPY and stimulates POMC pathways
- Appetite suppressing hormone
- decreased ghrelin release and appetite
- increased metabolism
- Appears to be part of negative feedback system for the regulation of food intake
Hormones released from the GI tract, pancreas, and adipose tissue regulate feeding behavior
-Ghrelin-secreted by?
Endocrine cells in the stomach