Lecture 1 Flashcards

1
Q

Define homeostasis

A

Condition: body’s internal environment remains relatively constant w/in limits

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2
Q

Conditions of homeostasis:

A
  • Optimum [ ] gases, nutrients, ions, and water

- optimal temperature and pressure for health of cells.

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3
Q

Define stress:

A

Any stimulus that creates an imbalance in internal environment

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4
Q

Most abundant cation in extracellular?

A

Na+ =sodium

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5
Q

Most abundant cation intracellular:

A

K+, potassium

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6
Q

Most abundant anion in the extracellular:

A

Chloride; Cl-

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7
Q

Define feedback system:

A

Circular situation in which the information about the status of something is continually reported to a central control region.

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8
Q
  • feedback
A

Most common. Response that reverses the direction of the initial condition; stabilizes the diminishing original response. Ex: Arterial BP to inhibit HTN by barorecptor sending inhibition signal to medulla.

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9
Q

+ feedback:

A

Response that intensifies initial condition. Destabilizing. ONLY healthy ex: cervix stretching causes stronger uterine contractions.

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10
Q

How do you calculate gain in a feedback system?

A

[Control system response - uncontrolled response] / ERROR

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11
Q

What is error when calculating gain?

A

Error is the amt. of uncorrected increase in the CONTROLLED system

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12
Q

Describe cell membrane w/ respect phospholipids and proteins.

A

“Unit membrane” has cholesterol inserted among the phospholipids. Proteins are asso. W/ the membrane. Hydrophobic tails of phospholipid and hydrophilic head groups.

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13
Q

What characteristic is necessary to pass across cell membrane?

A

Lipid soluble (hydrophobic) substances can readily pass

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14
Q

Peripheral proteins

A

Loosely attached to one surface or the other of membrane. Easily removed. Can be anchored by GPI-proteins.

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15
Q

Integral proteins:

A

Inserted in one side or pass al the way through and are exposed on either side of membrane.

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16
Q

Functions of plasma membrane:

A

Defines the intra/extracellular fluid composition. Filters, information exchange between the cell and environment; ends/exocytosis

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17
Q

Nucleus

A

Control center of the cell; houses the DNA of cell

18
Q

Endoplasmic reticulum

A

Network of tubular flat vesicles composed of lipid bilayer connected w/ nuclear membrane. Substances formed in other parts of the cell are conducted to other areas of the cell through matrix of the ER. Ribosomes attach to ER (RER). Other portions of the ER are smooth (SER)-lipid metabolism

19
Q

Ribosomes

A

can function to synthesize new proteins

20
Q

Golgi

A

Closely r.t ER….4 or more layers of stacked layers of thin, flat, enclosed vesicles lying near one side of the nucleus. it is located on the side of the cell where substances are extruded. Transport molecules molecules from the ER fuse to w/ the Golgi these substances then become lysosomes , secretory vesicles , and other cytoplasmic elements

21
Q

Mitochondria

A

Main function is houses cellular (aerobic) respiration.

22
Q

Lysosomes

A

Intracellular digestive system by way of hydrolytic enzyme. Ex: glycogen to glucose

23
Q

Peroxisomes

A

Similar to lysosomes but formed by self-replication (or budding from SER) contain OXIDASES [not hydrolases like lysosome] Important for alcohol digestion

24
Q

Endosomes

A

Provides environment for sorting p/t entering lysosomes

25
Q

With which function is clathrin asso. ?

A

Clathrin is asso. W/ endocytosis (pino/phagocytosis)—-form coated pits w/ or w/o receptors. Clathrin forms the inner pit or interior of Micelle that is created when taking a substance in.

26
Q

Characteristics of lysosomes

A

Contains hydrolases [hydrolytic enzyme] at low pH for interior of cell digestive system.

27
Q

How are secondary lysosomes made?

A

Primary lysosomes fuse w/ phagocytic vesicles to form secondary lysosomes

28
Q

What happens to undigested material?

A

Left behind w/in a residual body will be eliminated via exocytosis

29
Q

What organelles are asso. W/ protein synthesis?

A

Ribosomes, ER, and Golgi

30
Q

RIBOSOME role in protein synthesis:

A

Proteins are synthesized on ribosomes

31
Q

Proteins translated on RER are bound for:

A

Lysosomes or secretion

32
Q

Proteins translated on free ribosomes are bound for

A

Cytoplasm, nucleus, mitochondria, or to other cell membranes

33
Q

Glycolysis or Kreb’s cycle require O2?

A

Kreb’s. Glycolysis is anaerobic.

34
Q

End products of glycolysis:

A

Pyruvate X 2 [pyruvic acid]

35
Q

End products of Kreb’s:

A

CO2 and water

36
Q

Protein Intracellular trafficking from RER

A

Transport vesicles bud off ER and head to Golgi
Golgi further modifies protein.
Protein is then sent as secretory vesicles out of cell.

Or proteins can go to lysosome from RER

37
Q

Types of locomotion

A

Ameboid movement, cilia and flagella, and microtubules

38
Q

What uses ameboid movement in cell?

A

Macrophage and some other leukocytes

39
Q

Differ Cilia and flagella

A

Flagella moves the cell. Cilia moves material from cell while not moving.

40
Q

How are microtubules used for locomotion

A

Provide tracks on which motor molecules can move cargo