lecture 1 Flashcards

1
Q

Metabolism

A

The sum of all biochemical or chemical reactions carried out by a living organism

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2
Q

Catabolism

A

break down of organic materials and production of energy

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3
Q

Anabolism

A

synthesis of cellular complex components such as proteins, nucleic acids and consumption of energy

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4
Q

Primary Metabolism

A

The essential metabolic pathways that include both catabolic and anabolic processes for lipids, carbohydrates, proteins, and nucleic acids. Vital for the organism’s survival.

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5
Q

Intermediate Metabolites

A

Molecules produced during primary metabolism that can be used as building blocks for secondary metabolites.

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6
Q

Glycolysis

A

The metabolic pathway for glucose oxidation, generating ATP.

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7
Q

Citric Acid Cycle (Krebs’ Cycle)

A

A metabolic cycle that oxidizes acetyl-CoA to produce energy (in the form of GTP) and valuable intermediates.

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8
Q

Oxidative Phosphorylation

A

The process that disposes of electrons generated in glycolysis and the citric acid cycle to produce ATP.

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9
Q

Pentose Phosphate Pathway

A

A metabolic pathway responsible for the synthesis of pentoses and providing reducing power (NADPH) for anabolic reactions.

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10
Q

Urea Cycle

A

A series of reactions that convert toxic NH4+ into less harmful forms for excretion.

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11
Q

Fatty Acid β-Oxidation

A

The breakdown of fatty acids into acetyl-CoA, which can be used for energy production.

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12
Q

Gluconeogenesis

A

The synthesis of glucose from smaller precursors, important for providing glucose to the brain.

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13
Q

Secondary Metabolism

A

Metabolic pathways that occur outside of primary metabolism, leading to the production of low molecular weight bioactive molecules.

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14
Q

Low Molecular Weight Molecules

A

Small-sized molecules produced during secondary metabolism, often with specific bioactive properties.

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15
Q

Bioactive Molecules

A

Molecules with various biological effects, including antibiotic, cytotoxic, mutagenic, carcinogenic, teratogenic, immunosuppressive, and enzyme inhibitory properties.

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16
Q

Morphological Differentiation

A

The specific stage of development in an organism that often correlates with the production of secondary metabolites.

17
Q

Independent Growth

A

The producer organism can grow and survive without synthesizing these secondary metabolites, which are not essential for basic cellular functions.

18
Q

Diversity of Secondary Metabolites

A

Over 100,000 different secondary metabolites have been identified from plants, fungi, and bacteria, showcasing the extensive diversity in nature.

19
Q

What are the Major classes of secondary metabolites

A
  • Polyketides (PKS)
  • Non-ribosomal peptides (NRP)
  • Terpenes (TP)
  • Indole alkaloids (IA)
20
Q

Polyketides (PKS)

A

Secondary metabolites found in bacteria, fungi, and plants.

21
Q

PKS Biosynthesis

A

They are synthesized through the decarboxylative condensation of acetyl-CoA or malonyl-CoA, a process similar to fatty acid synthesis.

22
Q

PKS Diversity

A

Polyketides form a diverse family of compounds with various functions.

23
Q

PKS Pharmacological Importance

A

Known for their pharmacologically significant properties, including antimicrobial, antifungal, antiparasitic, antitumor, and agrochemical activities.

24
Q

PKS Production

A

Produced in large quantities by biotechnology companies, highlighting their commercial importance.

25
Q

Non-ribosomal Peptides (NRPs)

A

Secondary metabolites derived from both proteinogenic and non-proteinogenic amino acids, including D-amino acids. They are synthesized by multidomain, multimodular enzymes known as NRPS.

26
Q

NRPs Ribosomal Involvement

A

Unlike ribosomal peptides, NRPs are not synthesized by ribosomes, and their assembly is independent of ribosomal processes.

27
Q

NRPs Structure

A

NRPs often have macrocyclic and/or branched structures, which contribute to their diverse functions.

28
Q

NRPs Functions

A

NRPs serve various roles, including being siderophores (iron-binding compounds), toxins, pigments, antibiotics, cytostatic agents (inhibiting cell growth), and immunosuppressants.

29
Q
A