Lecture 03

Question 1

Increase in cell number

Answer 1

Hyperplasia

Question 2

Increase in cell mass

Answer 2

Hypertrophy

Question 3

Signal molecules that lead to hypertrophy

Answer 3

Growth factors

Question 4

Signal molecules that lead to hyperplasia

Answer 4

Mitogens

Question 5

Signal molecules that suppress programmed cell death

Answer 5

Survival factors

Question 6

Mitogens, growth factors, and survival factors are (intra/extra)cellular signal molecules.

Answer 6

Extracellular

Question 7

Protein that increases the expression of early response genes

Answer 7

MAP kinase

Question 8

MAP kinase is activated by ______.

Answer 8

Ras

Question 9

T or F. Myc is an early response genes that increases expression of other early response genes.

Answer 9

F. Myc is an early response genes that increases expression of DELAYED response genes.

Question 10

Factor that stimulates transcription of G1/S genes

Answer 10

E2F

Question 11

T or F: The Rb gene can be inactivated by a virus.

Answer 11

True

Question 12

4 mechanisms of RB inactivation

Answer 12

Genetic mutation
Viral inactivation
Phosphorylation
Degradation