Lectin Pathway

Question 1

Lectin pathway depends on

Answer 1

Mannose binding protein

Question 2

When mannan binding protein binds to mannose groups of microbial carbohydrates, it leads to

Answer 2

Activation of lectin pathway

Question 3

Where is lectin pathway synthesized

Answer 3

Liver

Question 4

List the organelles that have mannose and glucose in their cell wall

Answer 4

Salmonella
Candida
Neisseria

Question 5

List the lectin pathway protein that bind to MBP

Answer 5

MASP1 and MASP2

Question 6

Activated MASP-2 cleaves

Answer 6

C4 to C4a and C4b. (C4b binds covalently to microbial surfaces)
C2 into C2a and C2b

Question 7

C2a binds to C4b forming

Answer 7

The classical C3 convertase

Question 8

C5a3a4a triggers

Answer 8

Inflammation

Question 9

Importance of C5a

Answer 9

Chemotactically attract phagocytes to infection site

Question 10

Responsibility of C3b4b

Answer 10

1. Promote attachment if antigen to phagocytes via enhanced attachment or opsonization
2. Remove harmful immune complexes from the body

Question 11

What serves as a second signal for activation of naive B-lymphocytes

Answer 11

C3b

Question 12

What causes lysis of gram negative bacteria and human cells displaying foreign epitopes

Answer 12

MAC Membrane Attack Complex