lec_10_H_Influence_of_systemic_disorders_on_the_Periodontiu_28_12 Flashcards
The
number of……………………. increase with increased
levels of sex hormones in puberty
P intermedia Capnocytophaga
The severity of gingivitis is increased during pregnancy in
the 2 nd or
3 rd month and reaches its peak in 8 th month (hormones rise to its
maximum in eight month)
•
There is also a marked reduction in the severity of gingivitis occurs
2
months postpartum (decrease secretion of these hormones), and
after 1 year the condition of the gingiva is normal
•
P. intermedia increase greatly due to
the increased levels of estrogen
& progesterone which substitute menadione (vitamin K); an essential
growth factor. Periodontitis during pregnancy increases the risk for
preeclampsia by 2 2.5 folds.
•
Oral contraceptive pill contains
progesteron
often combined with an estrogen
•
Metronidazole should not be prescribed to
females taking oral contraceptives to
avoid the
risk of drug interaction that can lessen the
contraceptive effect
The gingiva remaining oral mucosa are dry, shiny and
vary in color from abnormal paleness to redness and easy
bleeding, burning sensation & altered taste
senile atrophic
gingivitis
WBCs are involved in
inflammatory reactions
necessary for cellular defense against MO
RBCs are responsible for
gas exchange
nutrient supply to the periodontal tissues
•
Platelets are necessary for
normal hemostasis
as well as recruitment of cells during
inflammation and wound healing
The leukemias are malignant neoplasias of WBCs precursors
characterized by
1.
Replacement of bone marrow with proliferating leukemic cells
(resulting in reduced production of RBCs, WBCs and platelets,
leading to anemia, leukopenia thrombocytopenia,
respectively)
2.
Abnormal numbers forms of immature WBCs in the
circulating blood
3.
Widespread leukemic cells infiltrate in the liver, spleen, lymph
nodes, other body sites
Deep punched out ulcers covered by a white slough can be found
on
the oral mucosa, that occur at sites of trauma such as the buccal
mucosa
blood disorder that results in low levels of
circulating neutrophils
Neutropenia
neutropenic episodes of 1 week duration
every 3 weeks)
cyclic Neutropenia
Agranulocytosis occurs if the counts drop below
500 /mm 3
Causes of Neutropenia
1.
It can be genetic (Familial neutropenia
2.
Drug induced (e g patients receiving chemotherapy for cancer)
3.
It may immune either auto immune ( or allo immune
(from other person as after blood transfusion)
4.
2 ry to other disease as SLE lymphoma
Neutropenia Effects
1.
Infections that may be life threatening
2.
Ulceration in the oral cavity, that is characterized by the
absence of a notable inflammatory reaction around ulcer
caused by lack of granulocytes (a striking feature)
3.
Gingival hemorrhage, necrosis, periodontitis fetid odor
Systemic conditions associated with
neutrophil functional defects وقالت مهم وأسئلة وبتاع فاحفظ
slide 17/18 in pdf lecture
IL-1 is catabolic cytokine that promotes
bone resorption and
collagen destruction
Severe
vitamin C deficiency in humans results in
scurvy (defective collagen
formation a disease characterized by delayed wound healing hemorrhagic
diathesis Bleeding, swollen gingiva ( mobile teeth and increased
susceptibility to infection are oral features of scurvy
PMN count in peripheral blood is
3000
6000 /mm 3
Agammaglobulinemia
•
It is an immune deficiency resulting from inadequate antibody
production caused by a deficiency in B cells
HIV associated Gingival & periodontal
diseases
• 1 . Linear gingival erythema • 2 . Necrotizing ulcerative gingivitis • 3 . Necrotizing ulcerative periodontitis • 4 . Necrotizing stomatitis
IL
1 is catabolic cytokine that promotes
bone resorption and
collagen destruction
There
is association between IL 1 gene polymorphism &
advanced periodontal disease
