LEC06 Flashcards
Folding Proteins
1
Q
How many structure levels are proteins broken up into?
A
Four.
2
Q
What is included in the primary structure?
A
- Amino acid sequence
- Drawn from amino acid end to the carboxyl end
- Numbering starts from amino acid end
3
Q
What is included in the secondary structure?
A
- Local spatial arrangement of the polypeptide chain
- Two regular arrangements
- alpha helix; residuals stabilised by hydrogen bonds
- beta sheet; adjacent segments stabilised by
hydrogen bonds
- Regular repeating structures are hydrogen bonded
4
Q
What is included in the tertiary structure?
A
- Overall 3D shape
- Results from non-covalent interactions between amino acids and side chains (R)
5
Q
What is included in the quaternary structure?
A
- Assembly of the polypeptide chain
- Can be identical or different in sequence
- The alpha and beta represent that the polypeptides have different primary structures
6
Q
What does myoglobin do?
A
- Stores and transports oxygen to muscle cells
- Important for aquatic animals so they can store air underwater
- Single polypeptide monomer
7
Q
What does haemoglobin do?
A
- Transports oxygen through veins and arteries
- In red blood cells
- Heme group is attached to polypeptide by non-covalent bonds
