[LEC] UNIT 1 - INTRO TO SI (HISTORICAL PERSPECTIVE) Flashcards
Branch of biology that covers the study of immune systems in all organisms
Immunology
Immunology is the study of molecules, organs, systems responsible for the ______ and _______ of foreign material
recognition ; disposal
Scientific study of serum and other body fluids
Serology
In 430 BC, he recorded that individuals who had previously contracted plague recovered
Thucydides
Thucydides recognized the ________ _______ of individuals
immune status
In 1000 AD, ________ practiced a form of immunization by inhaling dried powders derived from smallpox lesions (variolation)
Chinese
First recorded attempts to deliberately induce immunity took place in the ____ century
15th
In the 15th century, people in China and Turkey inhaled powder made from
smallpox scabs
Successfully prevented infection with smallpox by
injecting a less harmful substance—cowpox—from a
disease affecting cows
Edward Jenner
T or F: Edward Jenner was a German country doctor
F
English
What did Haeckel discover in 1862?
Phagocytosis
Observed by chance that older bacterial cultures
accidentally left out on a laboratory bench for the
summer would not cause disease when injected
into chickens
Louis Pasteur
Father of Immunology
Louis Pasteur
What kind of vaccine did Louis Pasteur discover?
Live attenuated
In 1885, live attenuated vaccine for _______ was first reported
rabies
Cellular theory of immunity through phagocytosis
Élie Metchnikoff
awarded the first Nobel Prize in Physiology for his work with serum therapy
Emil Von Behring
Theory proposed by Emil Von Behring and Shibasaburo Kitasato in 1890
Humoral theory of immunity
demonstrated that diphtheria and tetanus
toxins, which are produced by specific microorganisms
as they grow, could be neutralized by the noncellular
portion of the blood, or serum, of animals previously
exposed to the microorganisms.
Behring
Demonstration of cutaneous (delayed-type) hypersensitivity
Koch
Proponent of the antibody formation theory
Ehrlich
Discovered immediate hypersensitivity anaphylaxis
Portier and Richet
Linked the two theories (cellular immunity vs. humoral immunity
Almroth Wright
Certain humoral/circulating factors that acted to
coat bacteria so that they became more
susceptible to ingestion by phagocytic cells
Almroth Wright
increase nonspecifically in any infection
Acute-phase reactants
Arthus reaction of intermediate hypersensitivity was proposed by
Nicolas Maurice Arthus
Hypothesis of antigen-antibody binding was proposed by
Marrack
Hypothesis of allograft rejection was proposed by
Medawar
What did Salk and Sabin discover in 1949?
Polio vaccine
Discovered vaccine against yellow fever in 1951
Reed
Graft-versus-Host reaction in 1953
Dick W. van Bekkum
Clonal Selection Theory in 1957
Burnet
Discovered Interferon (viral interference)
Alick Isaacs and Jean Lindemann
Discovered Human Leukocyte Antigen or HLAs
Jean Dausset
T cell and B cell cooperation in immune cooperation
Henry Claman
Identification of antibody molecule
Edelman and Porter
First monoclonal antibodies
Kohler, Milstein
Identification of genes for T cell receptor
James P. Allison
Pablo DT Valenzuela discovered
Monoclonal hepatitis B vaccine
Th1 versus Th2 model of T helper cell function in 1986
Mossman
Identification of Toll-like receptor in 1996 to 1998
Jules Hoffman and Bruce Beutler
Gene discovered by Ramsdell and colleagues
FOXP3
the gene directing regulatory T cell development
FOXP3
Development of human papilloma virus (HPV) vaccine in 2005
Ian Frazer