Lec: Megakaryopoiesis and Platelet Flashcards
IL-3, GM-CSF, and M-CSF are required for the conversion of?
Hematopoietic Stem Cell to Common Myeloid Progenitor
The factor that stimulates the conversion of megakaryocyte progenitor to erythrocytes
EPO (Erythropoietin)
Factors that stimulate the conversion to megakaryocyte erythroid progenitor
IL-3, SCF (stem cell factor), TPO (thrombopoietin)
IL-11 and TPO stimulates the conversion of Megakaryocyte Progenitor to?
Platelets
The largest hematopoietic stem cell in the bone marrow
Megakaryocyte/ Mature Megakaryocyte
This is unique only in the megakaryocytic series
Endoreduplication (endomitosis) (๑>◡<๑)
It is a process whereby the nuclear material reduplicates but the nucleus does not divide
Endoreduplication or Endomitosis
The three progenitor cells carry the marker?
CD34 (ノ^_^)ノ
What are the 3 Progenitor Cells?
- Burst forming unit (BFU-Meg)
- Colony forming unit (CFU-Meg)
- Light density- CFU (LD-CFU- Meg)
These carry the marker CD42
MK-I, MK-II, MK-III
Hormones/ cytokines responsible for the transformation of MK-I to MK-II (Differentiation to Megakaryocytes)
TPO, L-3, L-11
Hormones/ cytokines responsible for the transformation from granualr to mature ( Late maturation)
TPO, L-6_ L-11
Hormones/ cytokines responsible for thrombopoiesis
L-6, L-11
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IDENTIFY:
Cytoplasm is more abundant, less basophilic, and granules begin to form
Promegakaryocyte
IDENTIFY:
Cytoplasm contains coarse clumps of granules aggregating into little bundles, which bud off from the periphery to become platelets.
Mature megakaryocyte
IDENTIFY:
Its nucleus is round, oval and has multiple nucleoli
Megakaryoblast