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Hematology 2 > Lec: Megakaryopoiesis and Platelet > Flashcards

Lec: Megakaryopoiesis and Platelet Flashcards

1
Q

IL-3, GM-CSF, and M-CSF are required for the conversion of?

A

Hematopoietic Stem Cell to Common Myeloid Progenitor

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2
Q

The factor that stimulates the conversion of megakaryocyte progenitor to erythrocytes

A

EPO (Erythropoietin)

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3
Q

Factors that stimulate the conversion to megakaryocyte erythroid progenitor

A

IL-3, SCF (stem cell factor), TPO (thrombopoietin)

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4
Q

IL-11 and TPO stimulates the conversion of Megakaryocyte Progenitor to?

A

Platelets

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5
Q

The largest hematopoietic stem cell in the bone marrow

A

Megakaryocyte/ Mature Megakaryocyte

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6
Q

This is unique only in the megakaryocytic series

A

Endoreduplication (endomitosis) (๑>◡<๑)

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7
Q

It is a process whereby the nuclear material reduplicates but the nucleus does not divide

A

Endoreduplication or Endomitosis

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8
Q

The three progenitor cells carry the marker?

A

CD34 (ノ^_^)ノ

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9
Q

What are the 3 Progenitor Cells?

A
  1. Burst forming unit (BFU-Meg)
  2. Colony forming unit (CFU-Meg)
  3. Light density- CFU (LD-CFU- Meg)
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10
Q

These carry the marker CD42

A

MK-I, MK-II, MK-III

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11
Q

Hormones/ cytokines responsible for the transformation of MK-I to MK-II (Differentiation to Megakaryocytes)

A

TPO, L-3, L-11

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12
Q

Hormones/ cytokines responsible for the transformation from granualr to mature ( Late maturation)

A

TPO, L-6_ L-11

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13
Q

Hormones/ cytokines responsible for thrombopoiesis

A

L-6, L-11
(੭ु｡╹▿╹｡)੭ु⁾⁾

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14
Q

IDENTIFY:

Cytoplasm is more abundant, less basophilic, and granules begin to form

A

Promegakaryocyte

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15
Q

IDENTIFY:

Cytoplasm contains coarse clumps of granules aggregating into little bundles, which bud off from the periphery to become platelets.

A

Mature megakaryocyte

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16
Q

IDENTIFY:

Its nucleus is round, oval and has multiple nucleoli

A

Megakaryoblast

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17
Q

IDENTIFY:

Multiple nucleoli are visible.
irregular in shape. may show lobulation.

A

Promegakaryocyte
☝( ◠‿◠ )☝

18
Q

It is the first stage in the Megakaryopoiesis that does not contain nucleolus

A

Granular Megakaryocyte

19
Q

IDENTIFY:

Nucleus: Multiple nuclei or may show multi-lobulation, Chromatin is coarser. No nucleoli are visible.

A

Granular Megakaryocyte

20
Q

Occurs as a reserve in case of trauma in the body (ex. hemorrhagic or unexpected bleeding)

A

Splenic Platelet Pool

21
Q

IDENTIFY:

Nucleus: Multilobulated. No nucleoli visible.

A

Mature megakaryocyte

22
Q

IDENTIFY:

2-4 um in size, Cytoplasmic fragments of megakaryocyte and it has no nucleus

A

Platelets (Thrombocytes) ٩(●ᴗ●)۶

23
Q

What is the function of platelets?

A

Primary Hemostasis and Maintaining Capillary Integrity

24
Q

Platelet normal range:

A

150,000-450,000/ uL

25
Q

Platelet normal function

A

> 100,000/uL

26
Q

Hemorrhage happens if the platelet count is?

A

<10,000/uL

27
Q

These are major glycoproteins responsible for Primary Hemostasis

A

GP Ib and GP IIb/ IIIa Complex
ヾ(＠^▽^＠)ﾉ

28
Q

This part of the platelet structure is composed of the membranes and is responsible for platelet Adhesion and Aggregation

A

Peripheral zone

29
Q

This is composed of the Mitochondria, Alpha granules, dense bodies (delta granules)

A

Organelle Zone

30
Q

Invaginations of the plasma membrane for release of granule content during platelet activation process.

A

Surface Connecting system (Open Canalicular system)

31
Q

Composed of protein tubulin that maintains the
shape of platelets

A

Microtubules ┗|・o・|┛

32
Q

Glycoprotein responsible for Platelet Adhesion

A

GP Ib

33
Q

Glycoprotein responsible for Platelet
Aggregation

A

GP IIb/ IIIa Complex

34
Q

A Cofactor in Fibrin Formation is released from?

A

Alpha Granules

35
Q

Which Zone has the receptors necessary for platelet Aggregation?

A

Peripheral Zone

36
Q

Granule formation occurs in?

A

Promegakaryocyte
୧〳 ＾ ౪ ＾ 〵୨

37
Q

One of the sources of Calcium during Platelet aggregation can be found in?

A

Dense Tubular system

38
Q

Von Willebrand Factor (vWF) participates in?

A

Platelet Adhesion

39
Q

Responsible for Platelet shape:

A

Sol Gel Zone and Structural Zone

40
Q

Provide negative charged phospholipid surface for Factor V and II activation

A

Platelets

41
Q

Endoplasmic Reticulum that sequesters calcium for Platelet activation

A

Dense Tubular System

42
Q

PF3 is found in which component of the Platelet?

A

Peripheral Zone
ヾ（⌒ヮ⌒）ゞ

Hematology 2 (6 decks)

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