Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

247 > Lec 8: Infertility Drugs > Flashcards

Lec 8: Infertility Drugs Flashcards

1
Q

Infertility: Inability to conceive after ….. months of ……. intercourse

A

12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Fecundability

A

Likelihood of conception per month of exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

The most prevalent cause of infertility in female is…

A

Amenorrhea/ovulatory dysfunction due to hypothalamic/pituitary causes (51%) or PCOS (30%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The most prevalent cause of infertility in men is…

A

Primary hypogonadism (high FSH) 30% but really 50% is unknown

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Female infertility causes (conditions)

A

PCOS, endometriosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Therapy for females

Anovulatory: …..
Tubal occlusion: …..

A

A: ovulation inducers
B: corrective surgery/ IVF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Does mild endometriosis impair fertility?

A

No, only moderate to severe do.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What can endometriosis impair

A

Folliculogenesis, fertilization, implantation, adhesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Treatment of endometriosis depends on ….. and …..

A

A: severity
B: need to become pregnant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Pain medication for endometriosis?

A

Ibuprofen, naproxen

NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Why and when does endometriosis cause pain?

A

Thickening and expulsion of ectopic endometrial implants causes pain.

When it is time for menstruation(?)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

If endometriosis patient does not want to have a child, taking only ……. will suffice.

A

Hormonal contraceptives (birth control pills, patches, rings)

Only mild to moderate endometriosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

GnRH agonist and antagonist treat endometriosis by …

You take low doses of …..and …. with this because it helps……

Can you get pregnant again after stopping meds?

A

Blocks prod. of FSH LH, lowers estrogen, thus prevents menstruation

Take low doses of estrogen and progesterone with it to help prevent symptoms of artificial menopause

Yes!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Medroxyprogesterone (depo-provera)

A

Long-acting progestin
(Antiestrogenic and androgenic activities)

Halt menstruation and growth of endometrial implants in endometriosis

Treat endometriosis

AE: weight gain, decrease bone prod., depressed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Danazol

A

Androgen derivatives

Inhibit FSH, LH prod. —> prevent menstruation

Major use: treat endometriosis **

Can cause serious SE to mum and baby thus not first choice

SE: F turns into M, liver enz. increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Is conservative surgery a sure fire way of treating severe endometriosis?

A

No, it can come back but the benefit is your reproductive organs are still intact

17
Q

Symptoms of PCOS

A
  • High insulin levels (resistance)
  • excessive male hormones —> secondary male characteristics
  • fertility issues
  • anxiety/depression
18
Q

How is PCOS commonly treated?

A

By symptoms

High fat cell amount but low leptin —> excess feeding and obesity

19
Q

Antiandrogenic agents for PCOS treatment

A

Spironolactone - diuretic, block effect of androgen

20
Q

Low ….. levels in the blood maybe effective in restoring menstruation and reduce PCOS health risks. Also reduces prod of T, thus help diminish symptoms such as acne and alopecia.

What drugs are needed for this?

A

Levels of insulin

  • glitazones (TZD- thiazolpdinediones)
  • metformin
21
Q

Treatment of infertility for patients with hyperprolactinemia (ovulatory dysfunction)

A

Dopamine agonists such as bromocriptine

22
Q

Ovulation induction?

A

Clomiphene citrate
-increae FSH through mod of negative fb

Gonadotropins

Pulsatile GnRH

23
Q

Gonadotropins are highly effective for patients with ….

Used to induce multiple follicles development in ….. and ….

Risk of hyperstimulation in ….. patients

A

Hypogonadotropic hypogonadism

Unexplained infertility and older reprod age women

PCOS patients

24
Q

Currently available gonadotropins…

A

Urinary prep. of LH and FSH —> HMG

Highly purified FSH + recombinant FSH —> metrodin

25
Q

In women ……. is used for ovulation induction.

In men, pulsatile …… can be used to treat hypothalamic causes of …….. deficiency

A

hMG, FSH, hCG, hLH

Pulsatile GnRH, gonadotropin

26
Q

In premenopausal women …… maintains secondary sexual characteristics, genitourinary tract mucosa (maintains moisture), and prevent premature osteoporosis

A

Low dose cyclical replacement of estrogen and progesterone

27
Q

Males with Secondary hypogonadism treatment?

A

Gonadotropins or pulsatile GnRH

28
Q

Severe defect in male treatment

A

IVF with intracytoplasmic sperm injection (ICSI)

29
Q

Initial diagnosis of male hypogonadism?

A

Testosterone levels (after sperm count)

Then gonadotropin levels to determine cause

247 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions