Lec 1: Pharmacology Of Pituitary And Hypothalamus Flashcards
Sermorelin
GHRH analogue
Treat GH deficiency (dwarfism)
GH insensitivity (receptor mutation or antibodies destroy)… what happens?
Proportionately short because no IGF-1
Tertiary GH deficiency will work when GHRH is given?
Yes! Because GHRH receptors still intact —> can still make GH from anterior pit
Somatropin
GH analogues
Clinical indications:
- confirmed GH deficiency
- panhypopituitarism (at lease 3 axes affected)
- idiopathic short statue
- chronic kidney disease
- Turner’s syndrome
- Prader-Willi syndrome
Mecasermin
IGF-1 analogue
GH Insensitivity —> Laron’s Dwarfism
A/E: hypoglycemia, intracranial hyperten (rare)
Octreotide
Somatostatin receptor ligand -long acting peptide
MAIN TREATMENT - somatotroph adenoma
MIAN TREATMENT AS GP - espphageal varicosities
How does octreotide treat e…… ……?
Esophageal varices
By inhibiting vasodilation of mesenteric vein caused by glucagon
Whats the difference in giving DA agonist in normal people (physiologic) and pathologic conditions?
In pathologic conditions e.g. acromegaly DA reduces GH release
But in physiolgic conditions DA promotes GH release
Dopamine receptor agonist examples
Bromocriptine, cabergoline
Pegvisomant
GH recptor antagonist
Analogue, competitive antagonist, prevent dimerization
Therapy for prolactinomas and side effect
Bromocriptine , N/V
Why is Thyrotropin given before radioactive iodine treatment of thyroid cancer
Maximize uptake of radioactive iodine because thyroid gland want hormone a lot because thyrotrophs have low free hormones (?) and want to get rid of radioactive iodine
Menotropins function
FSH LH containing follicle growth stimulant
Urofollitropin, follitrppin a, b
FSH
Use: stimulating ovulation may cause OVARIAN HYPERSTIMULATION SYNDROME
GnRH binds to ….. receptors on gonadotrophs
G protein coupled
