lec 8

Question 1

Chronic NSAID ingestion leads to

Answer 1

1. Peptic ulceration
2. symptoms of nausea and dyspepsia
3. gastrointestinal bleeding or perforation

Question 2

NSAID-related peptic ulcers usually occur

in the

Answer 2

stomach ,duodenal ulcers are much less common

Question 3

percentage of developing symptoms of nausea and dyspepsia form NASID

Answer 3

50% of patients

Question 4

percentage of developing Peptic ulceration form NASID

Answer 4

30% of patients

Question 5

percentage of developing gastrointestinal bleeding or perforation form NASID

Answer 5

1.5% of patients who develop

an ulcer.

Question 6

Risk factors for NSAID

Answer 6

21

Question 7

H pylori and NSAID appear to have

Answer 7

additive effect.

Question 8

H pylori and NSAID act independently to

Answer 8

increase ulcer & related bleeding

Question 9

corticosteroid therapy

Answer 9

are not by themselves a risk factor for ulceration but increase PUD risk مع NSAID

Question 10

rheumatoid arthritis, tobacco smoking, and

alcohol consumption

Answer 10

postulated to increase PUD risk in a patient taking an NSAID

Question 11

NSAIDs cause gastric mucosal damage by two primary mechanisms

Answer 11

1. Direct or topical irritation of gastric epithelium

2. Systemic inhibition of endogenous mucosal prostaglandin synthesis

Question 12

Direct irritation of the mucosal lining by NSAIDs occurs because

Answer 12

weak acids.

Question 13

Topical irritation is therefore most pronounced with

Answer 13

more acidic NSAIDs such as aspirin

Question 14

While the direct irritant effects of NSAIDs play a contributory يساهمrole in the
development of

Answer 14

NSAID-induced gastritis

Question 15

the direct irritant effects of NSAIDs generally plays a minor role in the evolution of

Answer 15

NSAID-induced PUD.

Question 16

The systemic effects of NSAIDs are the primary cause of

Answer 16

PUD

Question 17

COX-1 is routinely found

Answer 17

in body tissues for normal physiologic maintenance.

Question 18

e COX-1 Produce

Answer 18

PGE1
PGE2
PGI2
.

Question 19

COX-2 is expressed during states in which

Answer 19

cytokines and inflammatory mediators are elevated (e.g., fever and pain).

Question 20

type administration of NSAIDs incidence of PUD

Answer 20

oral ,parenterally and rectally

Question 21

Prostaglandins effectsالوظيفة افسيولوجية الهم

Answer 21

a. Stimulation of both mucus and phospholipid production.
b. Promotion of bicarbonate secretion.
c. Increased mucosal cell turnover

Question 22

(e.g of topical NSAID

Answer 22

Diclofenac: voltarin

Question 23

Diclofenac: voltarin

Answer 23

dose not cause PUD given the very low

serum concentrations t

Question 24

(e.g of parenterally NSAIDs

Answer 24

Ketorolac

Question 25

(e.g of rectally NSAIDs

Answer 25

indomethacin

Question 26

platelet effects of Prostaglandins

Answer 26

decrease bleeding complications

associated with peptic ulcer

Question 27

s 26

Answer 27

حفظ

Question 28

Other Causative Factors of ulcer

Answer 28

1. Cigarette smoking
2. Psychosocial factors such as life stress, baseline personality patterns, and depression
3. Dietary factors such as coffee, tea, cola, beer, and a highly spiced diet may cause dyspepsia,

Question 29

caffeine increases

Answer 29

gastric acid secretion

Question 30

alcohol ingestion causes

Answer 30

acute gastritis

Question 31

s 27

Answer 31

kkk + 28