LEC 1 (Interstitial cells of Cajal )

Question 1

Interstitial cells of Cajal location

Answer 1

between the smooth muscle

1. in the wall of the stomach ,small intestine (in the outer circular muscle layer near the myenteric plexus)
2. In the colon(in the sub-mucosal layer.)
3. large intestine.

Question 2

Interstitial cells of Cajal df

Answer 2

are specialized pacemaker cells connected to the smooth muscle and the myentric plexus via gap junctions.

Question 3

The functions of interstitial cells of Cajal are

Answer 3

(a) Generation of electrical slow wave activity
(b) active propagation of slow waves
(c) coordination of pacemaker activity
(d) transduction of motor neural inputs
(e) mechano-sensation to stretch of GI muscles
(f) setting the membrane potential gradient of gut smooth muscles.

Question 4

interstitial cells of Cajal have the capacity to

Answer 4

generate the basic electric rhythm or slow wave of smooth muscle

Question 5

The interstitial cells of cajal are

transduction of motor neural inputs from

Answer 5

from the ENS to the smooth cells enteric nervous system 
                              ↓   
interstitial cells of Cajal transmit 
                                ↓
to the smooth cells

Question 6

characterizes OF cajal cell

Answer 6

stellate 2. single nucleus 3.pacemaker cells4. with smoth muscle-like
feature that 5.send long multiply branched processes into the intestinal smooth muscle.

Question 7

classification of ICC according to their

location of muscle layer

Answer 7

1. intra-muscular
2. myenteric
3. sub-muscular

Question 8

intra-muscular ICC

Answer 8

stimulation of smooth muscle cells, neurotransmitters act through them

Question 9

myenteric ((ICC-MY)

Answer 9

pacemake → bioelectrical slow wave that → contraction of SM

Question 10

sub-muscular ICC

Answer 10

stellate and bipolar)

Question 11

classification of ICC according to their primary function

Answer 11

1. pacemakers
2. mediate neuromuscular neurotransmission
3. mechano-reception