lec 8-10 kahoot Flashcards
An ABC Transporter uses which of the following transport mechanisms?
primary (A)ctive transport
A = ATP
efflux (out of cell)
PRIMARY ACTIVE TRANSPORT
unidirectional
SLC transporters
substrate uptake (into cell)
facilitated diffusion
SECONDARY/TERTIARY active transport
bi-directional
antiporter
Which of the following transport mechanisms involves ions of the same charge moving in opposite directions
secondary active antiport (bi-directional)
GLUT-4 transporters are insulin ____________
sensitive
GLUT-4 transporters are insulin-sensitive
Which of the following decontamination methods will reduce drug effectiveness after it has entered the bloodstream?
antidote treatment e.g. NAC
Are the ß1 adrenergic receptor and ß2 adrenergic receptor considered to be the same receptor therefore the same target?
no
Which type of adverse drug reaction is an expected dose-related effect of a drug?
augmented (dose-related)
A(n) ___ metabolizer requires a lower concentration of a drug should it be metabolized by an enzyme with a polymorphism
poor
low poor>intermediate>extensive>ultrarapid highest conc ?
Which of the following SNPs involves only the addition of a nucleotide?
insertion
A mutation that decreases P-gp effectiveness will cause a(n) ____ in drug plasma concentration.
increase
blocks efflux?
If you inhibit either uptake or efflux transporters in kidney, then ________ clearance of drug in urine
Results in ______ bioavailability of drug in body
DECREASE; increase
inhibit uptake/efflux transporters = decrease clearance
A(n) _ metabolizer requires a lower concentration of a prodrug should it be metabolized by an enzyme with a polymorphism
ultra rapid
When considering prodrug, ______ metabolizers now require lowest dose
ULTRARAPID
Which of the following individuals would require the lowest dose of warfarin?
mutation with both
-CYP2C9
-VKORC1
