lec 7. ventralisation

Question 1

what does the notochord secrete

Answer 1

Shh

Question 2

Shh

Answer 2

secreted by the notochord, diffuses into ventral neural tube and induces expression of TFs in progenitor cells to acquire ‘ventral identities’ . also allows neurons to develop with bilateral symmetry around midline

Question 3

Hedgehog signalling pathway

Answer 3

Hh -| Ptc -| Smo -> Gli

Question 4

what types of neurons does Shh induce

Answer 4

forebrain -> hypothalamic neurons
midbrain -> dopaminergic neurons
hindbrain -> serotonergic neurons
spinal cord -> motor neurons

Question 5

Nk6.1 and Olig2

Answer 5

dictate later differentiation of ventral neural progenitors

Question 6

holoprosencephaly

Answer 6

caused by mutation in Shh which causes failure of ventral forebrain to develop into 2 hemispheres