LEC 6 Intro to Immunology II Flashcards

1
Q

What are the two forms of antibodies?

A
  1. Cell surface antigen receptor on B cells
  2. Secreted antibody
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2
Q

What is IgM?

A
  • B cell receptor
  • earlierst Ig produced
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3
Q

What is IgD?

A
  • Antigen receptor on B cells; co-expressed with IgM
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4
Q

What is IgG?

A
  • most prevalent in serum
  • 4 subclasses: IgG1, IgG2, IgG3, IgG4
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5
Q

What is IgA?

A
  • Most prevalent in secretions
  • 2 subclasses: IgA1, IgA2
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6
Q

What is IgE?

A
  • Immediate hypersensitivity
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7
Q

When expressed on B cells, IgM is a what?

A

Monomer

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8
Q

In its secreted form, IgM is a what?

A

Pentamer

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9
Q

How many antigen binding sites are there in the secreted form of IgM?

A

10

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10
Q

What holds the individual antibodies together in the pentamer form of IgM?

A
  • Disulfide bonds
  • J chain
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11
Q

What is the major isotype of antibody secreted at mucosal surfaces?

A

IgA

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12
Q

Where is IgA1 mostly found?

A
  • serum
  • and made by bone marrow b cells
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13
Q

Where is IgA2 mostly found?

A

mucosal secretions, colostrum and milk and is made by B cells located in the mucosa

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14
Q

IgA can exist as a what?

A

Monomer or dimer

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15
Q

What is an isotype?

A

determined by differences in the constant regions of heavy and light chains

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16
Q

What is an allotype?

A
  • polymorphisms within the Ig isotype
  • Minor variations within the constant regions
17
Q

What is an idiotype?

A
  • differences based on variable regions and antigen binding specificity
  • A monoclonal antibody has only one idiotype
  • Antibodies specific for a single epitope may have multiple idiotypes