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Disease & Defense > LEC 27 Viral Oncogenesis and Tumor Immunology > Flashcards

LEC 27 Viral Oncogenesis and Tumor Immunology Flashcards

1
Q

What virus is associated with Kaposi’s Sarcoma?

A

Kaposi’s Sarcoma Herpesvirus

Herpes virus 8; AIDS-associated disease

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2
Q

What virus is associated with cervical cancer?

A

Human Papillomavirus (HPV)

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3
Q

What are the high risk types of HPV?

A

HPV 16 and HPV 18

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4
Q

What type of cervical cancer is HPV16 associated with?

A

Squamous cell carcinoma

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5
Q

What type of cervical cancer is HPV 18 associated with?

A

Cervical adenocarcinoma

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6
Q

What’s the difference in Gardasil and Gardasil 9?

A

Gardasil 9 covers more HPV strains and does not contain aluminum

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7
Q

Lymphoma is associated with what virus?

A

Epstein-Barr Virus (EBV)

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8
Q

What two types of lymphoma are associated with EBV?

A
  • Burkitt’s Lymphoma
  • Hodgkin’s Lymphoma
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9
Q

What two genes are viral oncogenes associated with EBV?

A
  • EBNA2 - transactivates c-myc
  • LMP1 - mimics CD40 in B-cell activation
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10
Q

What is the target of Rituximab (Rituxan)? What disease does it treat?

A

CD20; B cell Lymphoma

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11
Q

What is the target of Trastuzumab (Herceptin)? What disease does it treat?

A

HER2/neu; Breast Cancer

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12
Q

What is the target of Bevacizumab (Avastin)? What disease does it treat?

A

VEGF; Colorectal cancer

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13
Q

What is the target of Cetuximab (Erbitux)? What disease does it treat?

A

EGFR; Colorectal Cancer

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14
Q

What is the target of Panitumumab (Vectibix)? What disease does it treat?

A

EGFR; Colorectal Cancer

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15
Q

What is the target of Alemtuzumab (Lemtrada)? What disease does it treat?

A

CD52; Chronic Lymphocytic Leukemia

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16
Q

What are the mechanisms of Rituximab-mediated cell killing?

A
  • CDC: Complement-dependent cytotoxicity
  • ADCC: Antibody-dependent cell mediated cytotoxicity
  • ADP: Antibody-dependent phagocytosis
17
Q

What is the target of Ipilimumab (Yervoy)? What is its use indicated for?

A

CTLA-4; Melanoma

18
Q

What is the target of Nivolumab (Opdivo)? What is its use indicated for?

A

PD-1; Melanoma, non-small cell carcinoma, renal cell carcinoma, urothelial carcinoma

19
Q

What is the target of Pembrolizumab (Keytruda)? What is its use indicated for?

A

PD-1; Melanoma, non-small cell carcinoma, renal cell carcinoma, urothelial carcinoma

20
Q

CAR-T therapies typically target what and are generally used to treat what diseases?

A

CD19; B-cell leukemias/lymphomas/myelomas

Drugs have words “gene” and “leucel” in them

20
Q

CAR-T therapies typically target what and are generally used to treat what diseases?

A

CD19; B-cell leukemias/lymphomas/myelomas

Drugs have words “gene” and “leucel” in them

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