LEC 28 Retroviruses and HIV Flashcards
1
Q
How was HIV discovered?
A
Young homosexual men that were otherwise healthy were dying from opportunistic infxns which suggested some sort of underlying immune disorder
2
Q
What is included within an HIV virion?
A
- Spherical, enveloped RNA virus
- 2 copies of RNA genome with 5’ cap and 3’ polyA tail
- Capsid contains reverse transcriptase, integrase, and protease enzymes
- gp41/gp120 form viral receptor complex
3
Q
HIV may show tropism for which cells?
A
Macrophages and CD4 T cells
4
Q
Newly acquired HIV infection shows tropism towards which cells?
A
Macrophages - HIV gp120 binds CD4 and CCR5 co-receptor
5
Q
T cell-tropic HIV utilizes which coreceptor on CD4 T-cells?
A
CXCR4
6
Q
What characterizes a progression of HIV infection to AIDS?
A
CD4 T cell count <200
