Lec 4 Flashcards
1
Q
Can drugs migrate to site of action?
A
Yes
2
Q
What does absorption, distribution, metabolism and excretion of a drug all involve?
A
Transport across cell membranes
2
Q
What does absorption, distribution, metabolism and excretion of a drug all involve?
A
Transport across cell membranes
3
Q
What factors affect drug characteristics of Absorption, distribution, metabolism, and excretion? (4)
A
- Molecular size
- Degree of ionization
- Lipid solubility of ionized and non ionized forms
- Affinity and binding to serum and tissue protein