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BIOM 3090 > CNS drugs > Flashcards

CNS drugs Flashcards

1
Q

What is an excitatory neurotransmitter?

A

Glutamate (NMDA)

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2
Q

What decreases the release of NMDA?

A

THC

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3
Q

What does NMDA do?

A

Increase ions from ion channel (Ca2+, Na+, K+)

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4
Q

What decreases NMDA receptor activation?

A

PCP and ethanol

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5
Q

What is an excitatory neurotransmitter that acts on NDMA receptor?

A

Glutamate

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6
Q

What do Ethanol and PCP do to NMDA receptors?

A

Decrease receptor activation

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7
Q

What is an inhibitory neurotransmitter?

A

GABA (GABAa)

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8
Q

What does GABAa do?

A

Increase Cl- conductance

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9
Q

What decreases the release of GABA?

A

THC

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10
Q

What increases the GABAa receptor activation?

A

Diazepam, Phenobarbital and Ethanol

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11
Q

What is an inhibitory neurotransmitter?

A

GABA

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12
Q

What do diazepam, Phenobarbital and ethanol do to GABAa?

A

Increase GABAa receptor activation

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13
Q

What are the 4 mixed action neurotransmitters?

A

Acetylcholine, Norepinephrine, Dopamine, and Serotonin.

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14
Q

What receptors does acetylcholine effect?

A

M/N

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15
Q

What cholinergic receptors are effected by lithium?

A

M1, M3, M5.

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16
Q

Are M2 and M4 receptors effected by lithium?

A

No.

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17
Q

What are acetylcholine M1, M3, M5 mechanisms?

A

G-protein - increases IP3, DAG, and decreases K+

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18
Q

What are acetylcholines M2 and M4 mechanisms?

A

G-protein - decreases cAMP

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19
Q

What are acetylcholines nicotinic mechanisms?

A

Ion channel - increasing Na+ and K+ conductance

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20
Q

What is an indirect agonist to acetylcholine?

A

Donepezil

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21
Q

What is an antagonist to acetylcholine?

A

Benztropine

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22
Q

What is Alzheimers disease?

A

Loss of cholinergic projection neurons (associated with memory)
Acetylcholine

23
Q

What receptors does norepinephrine effect?

A

Alpha 1, Alpha 2, Beta 1, Beta 2

24
Q

What adrenergic receptors effected by norepinephrine are also effected by lithium?

25
What mechanisms do norepinephrine alpha 1 receptors work through?
g-protein - increase IP3 and DAG and decrease K+ conductance
26
What mechanisms do norepinephrine alpha 2 receptors work through?
G-protein - decrease cAMP (inhibit it)
27
What mechanisms do norepinephrine Beta 1 and 2 receptors work through?
G-protein - increase cAMP
28
What increases the release of norepinephrine?
Amphetamine, Tyramine, and bupropion
29
What decreases the re-uptake of norepinephrine?
Imipramine, cocaine, and bupropion
30
what decreases the metabolism of norepinephrine?
Phenelzine
31
What alpha 2 agonist directly affects Norepinephrine? what does it do? through what mechanism?
Clonidine, to treat SNS withdrawal, through G-protein - cAMP inhibition
32
What receptors does dopamine effect?
D2
33
What mechanisms do dopamine D2 receptor work through
g-protein - decrease CA2+ (presynaptic) , and G-protein - increase K+ (postsynaptic)
34
What increases the synthesis of Dopamine?
L-Dopa
35
What increases the release of dopamine?
Amphetamine and bupropion
36
What decreases the re-uptake of dopamine?
Cocaine and bupropion
37
What decreases the metabolism of dopamine?
Phenelzine and selegiline
38
What Is a Dopamine D2 agonist
Ropinirole
39
What is a Dopamine D2 antagonist
Haloperidol and olanzapine
40
What is Parkinsons disease?
loss of nigrostriatal dopamine projection neurons
41
Excess and lack of dopamine results in what disease?
Schizophrenia
42
What receptor does serotonin effect?
5HT2A
43
What mechanism does serotonin 5HT2a receptor effect
G-protein - Increase IP3 and DAG and decreases K+ conductance
44
What increases the release of serotonin
amphetamine
45
What decreases the re-uptake of serotonin?
Imipramine, fluoxetine and cocaine
46
What decreases the metabolism of serotonin?
Phenelzine
47
What is a 5-HT2a agonist
LSD
48
What is a 5-HT2a antagonist
Haloperidol, olanzapine
49
what is reduced monoamine neurotransmission linked to?
Depression.
50
What receptor do opioids target
Mu
51
Are opioids pre- or post- synaptic or both?
Both pre- and post- synaptic
52
What are opioids linked to?
Inhibitory G-protein
53
What are Opioid agonist?
Heroine, morphine and methadone
54
What are Opioid antagonists? aka what do u give someone ODing on opioids
Naloxone

BIOM 3090 (5 decks)

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