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CC2 > LDH > Flashcards

LDH Flashcards

1
Q

systematic name of lactate dehydrogenase

A

EC 11127

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2
Q

LDH CATALYZES lactate to _

A

pyruvate

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3
Q

end product for ldh ?

A

pyruvate + NADH + H+

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4
Q

weight of ldh

A

128,000

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5
Q

two different polypeptide chains

A

h heart and m muscle

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6
Q

LD1 AND LD2 TS

A

heart, rbc, kidney

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7
Q

ld3 TS

A

LUNGS PANCREAS AND SPLEEN

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8
Q

LD4 AND LD5

A

SKELETAL MUSCLE, LIVER AND INTESTINE

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9
Q

PRESENCE OF LDH IN RBC

A

100-150

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10
Q

LDH2 IS MORE THAN LDH 1 MEANS:

A

NORMAL

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11
Q

LDH 1 >LDH 2

A

MYOCARDIAL INFARCTION

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12
Q

HIGHEST LDH INDICATES

A

HEMOLYTIC DISORDERS AND PERNICIOUS ANEMIA

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13
Q

LDH 1 WHICH IS IN THE HEART AND RBC CAN INDICATE:

A

MYOCARDIAL INFARCTION AND HEMOLYTIC ANEMIA

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14
Q

LDH 2 SAME ORGANS AS 1 INDICATES :

A

MEGALOBLASTIC ANEMIA, AMI, HEMOLYZED SAMPLE

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15
Q

LDH 5

A

SKELETAL MUSCLE INJURY AND HEPATIC DISORDERS

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16
Q

LDH 3, LUNG LYMPHOCYTES SPLEEN AND PANCREAS

A

PULMUNARY EMBOLISM, EXTENSIVE PULMONARY PNEUMONIA, LYMPHOCYTIS , AND ACUTE PANCREATITIS CARCINOMA

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17
Q

LDH 6

A

ALCOHOL DEHYDROGENASE

17
Q

LDH 4 IF SEEN IN LIVER

A

HEPATIC INJURY OR INFLAMMATION

18
Q

LDH 6 IN ARTERIOSCLEROTIC CV FAILURE

A

SIGNIFIES GRAVE PROGNOSIS AND IMPENDING DEATH

18
Q

THIS MIGRATES CATHODIC TO LDH 5

A

LDH 6

19
Q

LDH 6 IS ELEVATED IN :

A

DRUG HEPATOXICITY AND OBSTRUCTIVE JAUNDICE

20
Q

LDH 6 IS RESPONSIBLE FOR THE METABOLIC CONVERSION OF METHANOL AND ETHYLENE GYCOL TO:

A

TOXIC COMPOUNDS

21
Q

LD 1 PREFERS _ RX

A

FORWARD

21
Q

_ IS MORE SPECIFIC THAN _ IN THE ASSAY FOR LDH

A

LACTATE> PYRUVATE

22
Q

LD 5 PREFRES _ RX

A

REVERSE

23
Q

_ METHOD ( FORWARD )

A

WACKER

24
Q

PH OF WACKER :

A

8.8-9.8

25
Q

IT IS THE MOSTH COMMON METHOD

A

WACKER BOY !

26
Q

PRODUCT OF WACKER

A

PYRIVATE +NAD

27
Q

PH OF WROBLEUSKI

A

7.4-7.8

27
Q

T OR F WACKER IS AFFECTED BY PRODUCT INHIBITION

A

FALSE

28
Q

HAS REVERSE RX AND 3X FASTER THAN FORWARD RX

A

WROBLEUSKI LA DUE

29
Q

WROBLEUSKI NEEDS SMALLER VOLUME BUT HAS DISADVANTAGES:

A

SUSCEPTIBLE TO SUBSTRATE EXHAUSTION AND CAN CAUSE LOSS OF LINEARITY

30
Q

WIDELY USED ASSAY FOR LDH WHERE IN IT USES ISOENZYMES

A

ELECTROPHORESIS

30
Q

ISOENZYMES CAN BE DETECTED BY EITHER

A

FLOUROMETRICALLY/ COLORIMETRY

30
Q

PRODUCT OF WROBLEUSKI LADUE

A

LACTATE+NADH

31
Q

IF SAMPLE CANNOT BE PROCESSED IMMEDIATELY:

A

STORE AT 25C W/IN 25 HRS

32
Q

LDH _ is the most heat labile =, loss of activty starts at _c

A

5 AT 4C

33
Q

REFERENCE RANGE FOR LDH

A

100-225 U/L

34
Q

MOST ANODAL TO LEAST ANODAL IN NORMAL SERUM

A

LDH 2-1-3-4-5

35
Q

THE MAJOR ISOENZYME OF LDH THAT IS PRESENT IN HEALTHY IND.

A

LDH 2

36
Q

AMI AND INTRAVSCULAR HEMOLYSIS

A

LDH 1-2-3-4-5

CC2 (10 decks)

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