ALP Flashcards
transcribe alt and give its systematic name
ALKALINE PHOSPHATASE , EC 3131
PH OH ALP AND ITS ACTIVATOR
9-10 PH, MAGNESIUM
PRODUCT OF ALP
INROGANIC PHOSPHATE ION
LIST THE MAJOR ISOENZYMES OF ALP
LIVER ,BONE, PLACENTA AND INTESTINAL
HIGHEST ELEVATION:
HEPATOBILLIARY DISORDERS AND BONE DISORDERS
BILLIARY TRACT OBSTRUCTION
CAUSED BY THE SYNTHESIS OF THE ENZYME INDUCED BY CHLESTASIS, 3-10X ULN
HEPATOCELLULAR DISORDERS
< 3 ULN
SEEN IN PAGETS DX, OSTEOmalacia, ETC…. masakit na fingers ko
BONE ISOENZYME
SEEN IN DM, RENAL FAILURE AND CIRRHOSIS, SEN IN B T O AND B
INTESTINAL ISOENZYME
elevated after MEALS
INTESTINAL ISOENZYMES
SEEN IN PREGNANT WOMEN
PLACENTAL ISOENZYMES
NORMAL ULN OF PLACENTAL ISO IN WOMEN
1 1/2 ULN
ELEVATIONS MAY ALSO BE SEEN IN COMPLICATIONS OF PREGNANCY TRUE OR FALSE?
TRUE *BASTA MAY “cLAMPSIA”
ALP IS DECREASED IN _ AND _
HYPOPHOSPHATASIA AND ABSENCE OF BONE ISO
ALP ISO IN CANCER ALSO KNOWN AS :
CARCINO PLACENTAL ALKALINE PHOSPHATASE
MOST HEAT STABLE CANCER ALP ISO
REGAN ISOENZYME