Laxatives Flashcards
What combination of laxatives are used to treat opioid induced constipation?
Osmotic
Stimulant
Contra-indications for bulk forming laxatives?
Colonic atony Dysphagia Faecal impaction infective bowel disease intestinal obstruction
Side effects of bulk forming laxatives
Abdo distension (esp during first few days of treatment) Flatulence GI impaction GI Obstruction Hypersensitivity
Is there any issue with abruptly withdrawing treatment with any laxative?
None stated
Osmotic Laxatives contra-indications (Lactulose)
Galactosaemia
Intestinal obstruction
Osmotic Laxatives Contra-indications (macrogols)
Toxic Megacolon Crohns Paralytic ileus Severe Inflammatory conditions of the intestinal tract Ulcerative Collitis Intestinal obstruction
Osmotic Laxatives Contra-Indications (Sodium Salts)
Acute severe colitis (adults) Acites Congestive Cardiac failure Gastric retention Gastro Intestinal Perforation
Osmotic Laxatives Contra-Indications (Magnesium)
Acute GI conditions
Osmotic Laxatives Common side effects?
Abdo discomfort Cramps Flatulence nausea (help reduce by giving with water/juice/meals) Vomiting
Stimulant laxatives Contra-indications
Acute inflammatory bowel disease Acute surgical abdominal conditions (in adults) intestinal obstruction severe dehydration undiagnosed abdominal pain
Stimulant laxatives common side effects
Senna - Abdo spasm; discoloration of urine; pruritis
Bisacodyl - Abdo cramp; colitis; N&V
Prolonged/excessive use can lead to diarrhoea/hypokalaemia etc
Common side effects of H2 Receptor Antagonists?
Diarrhoea
Dizziness
Headaches
What short term conditions are PPIs used to treat?
Gastric/duodenal ulcers Dyspepsia GORD Erosive Oesophagitis Benign Gastric ulcers
What long term conditions are PPIs used to treat?
Hypersecretory conditions - zollinger ellisons
Maintenance therapy for healing peptic ulcers, erosive oesophagitis
Combined with amoxicillin and Clarythromycin to treat H.Pylori
What are the contra-indications for PPI use?
None stated