LAXATIVES

Question 1

Psyllium (Metamucil), what is this drug?

Answer 1

FIber

Question 2

What is the action of Psyllium?

Answer 2

adds bulk and size to fecal matter

Question 3

what is psyllium used for?

Answer 3

treat consitpation and bowel irregularity?

Question 4

what are the side effects of psyllium?

Answer 4

severe flatulence and abdominal bloating

Question 5

what are the contraindication of psyllium?

Answer 5

prescence of undiagnosed abdominal pain, can cause organ to inflame, rupture, and spill over into GI cavity

Question 6

what is a patient teaching with Psyllium?

Answer 6

take with a full glass of water

Question 7

What is Bisacodyl (dulcolax) action?

Answer 7

irritate GI mucosa pulls water into bowel lumen, moves through bowel quickly not allowing feces to absorb water

Question 8

What are the uses of Bisacodyl?

Answer 8

relief of constipation, bowel prep for surgery or medical examinations

Question 9

What are adverse effects of Bisacodyl?

Answer 9

abdominal pain, cramping, N/V and weakness

Question 10

what are the contraindications of Bisacodyl?

Answer 10

undiagnosed abdominal pain, intestinal obstruction or fecal impaction

Question 11

What liquid can interact with BIsacodyl?

Answer 11

Milk, it can decrease absorption and enteric coating of drug causing early release

Question 12

Bisacodyl can interact with what meds?

Answer 12

Antacids and H2 receptors

Question 13

what do we use Magnesium Hydroxide (Milk a Mag) for?

Answer 13

rapid evacuation of stool, fecal impaction, and to clean bowel for endoscopic exam

Question 14

Why is Milk a Mag not safe for prolonged use?

Answer 14

Can cause imbalance in electrolytes and fluid (dehydration)

Question 15

What do patient with renal impairment experience when taking milk a mag

Answer 15

Hypermagnesia due to being absorbed systemically

Question 16

What is the contraindications when giving Milk A Mag?

Answer 16

GI obstruction, gastric retention, colitis, and bowel perfusion

Question 17

What is the use of lactulose?

Answer 17

Decrease hepatic encephalapothy
decrease ammonia levels

Question 18

how do we know Lactulose is working?

Answer 18

Improved mental cognition
2-3 soft stools daily (diarrhea and loose bm’s do not indicate its working)

Question 19

What are the 3 NOT’s of Lactulose

Answer 19

NOT going to decrease portal HTN
NOT renally excreted (pee)
NOT going to decrease ascites

Question 20

What is the mechanism of action of Lactulose?

Answer 20

Pulls water into intestinal lumen
is a dissacharide that is not absorbed

Question 21

Peclanotide (Trulance, “-otide”) drug class?

Answer 21

GC-C antagonist

Question 22

What is the mechanism of action of Peclanotide?

Answer 22

Increase secretion of chloride and water and binds to the GC-C of intestinal epithelium

Question 23

What is the use of Peclanotide?

Answer 23

soften stools and stimulate BM’s

Question 24

when do we take Peclanotide?

Answer 24

we take this 30 min before our first meAL

Question 25

What is the black box warning of Peclanotide?

Answer 25

Not given to children <6yrs old due to leading death of dehydration

Question 26

what are the adverse effects of Peclanotide?

Answer 26

abdominal discomfort and diarrhea