Last Week Prep Flashcards
Etiology of pneumatosis intestinalis
Often due to poor perfusion to the gut, resulting in hypoxia and subsequent necrosis
As such, it may happen in premature babies OR babies with some risk factor for poor oxygen delivery to the gut
Malrotation anatomy
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Myelomeningocele is often associated with ___ and ___
Myelomeningocele is often associated with Chiari malformation II (inferior displacement of brainstem stuff) and obstructive hydrocephalus
More in depth Jones criteria
- Dx based on:
- Clinical or laboratory evidence of previous streptococcal infection
- 2 major criteria OR 1 major and 2 minor criteria
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JRA aka systemic juvenile idiopathic arthritis can only be diagnosed after. . . .
. . . symptoms have been present for at least 6 weeks
This is an easy way to help rule it out in questions
JRA arthritis usually does not. . .
. . . mirgate
A quick way to help rule it out in questions
If a kid expresses suicidal intent, then. . .
. . . you need to hospitalize them, regardless of parental consent
Umbilical granuloma
Presents in newborns after umbilical cord is separated
treat w/ topical silver nitrate
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Things that trigger methemoglobinemia and associated O2 sat and PaO2
- Triggers:
- Dapsone
- Topical anesthetics (lidocaine, etc)
- Nitrites
- O2 sat (by pulse ox: Low
- Actual PaO2: Normal
___ may be given to prevent or reduce airway obstruction in severe mononucleosis
Corticosteroids may be given to prevent or reduce airway obstruction in severe mononucleosis
Primitive reflexes and when they should disappear
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Retinoblastoma
- Unilateral when sporadic, bilateral when inherited
- Seriously, suspect this WHENEVER there is a white reflex and no evidence of cataract
- Strabismus and nystagmus may be present, OR patient may be totally asymptomatic with perfect vision
- Diagnosis is confirmed with MRI
- DO NOT biopsy. This can seed the tumor.
- Treatment depends on stage (surgery, chemo), but we avoid radiation since this can trigger cancer in the other eye in some people.
VZV Ig
It exists
Monoclonal antibody against VZV
Give to babies for post-exposure prophylaxis
Kidney biopsy finding in Alport syndrome
Longitudinal splitting of the GBM
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Niemann-Pick vs Tay-Sachs
Key takeaways for differentiation:
- NP there is hepatosplenomegaly and no reflexes
- TS there is hyperreflexia and no hepatosplenomegaly
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What tests do you need to order for a new diagnosis of Kawasaki disease?
EKG and Echo
Bone pain + systemic signs
Leukemia!!!
Don’t forget that leukemia causes bone pain too
Dactylitis in sickle cell
Pain in acral regions due to sickling within distal arteries of extremities
Second most common surgery in sickle cell patients
Tonsillectomy
For Waldeyer’s Ring hyperplasia. Very common in sickle cell patients.
Thumbs in the congenital anemias
Diamond Blackfan: Triple phalangeal thumbs
Fanconi: No thumbs
Two most common brain tumors in childhood
- Astrocytoma. Good prognosis.
- Medulloblastoma. Bad prognosis. Often blocks 4th ventricle.
Hypertension + abdominal mass in a child
Wilm’s tumor
Intrathecal methotrexate in ALL
Always add this to therapy! It prevents recurrence of ALL within the CNS
Reasons a kid might fall off the growth curve
- GH loss
- Sellar mass
- Hypothyroidism
- Turner’s
6-9-15-30 rule of motor development
6 months: Roll over
9 months: Sit upright unsupported
15 months: Walk
30 months: Climb stairs
Urinary incontinence is pathologic after age ___.
Fecal incontinence is pathologic after age ___.
Urinary incontinence is pathologic after age 5
Fecal incontinence is pathologic after age 4
MMRV contains ___, which some people are allergic to.
Neomycin
Transposition of the Great Arteries features
- Adding O2 will not affect saturation at all
- No murmur (only cyanotic CHD without one)
- Diabetic mother
Why do bipolar moms give birth to babies with WPW syndrome?
Bipolar mom -> Lithium -> Ebstein anomaly -> WPW syndrome
Associations w/ PDA
Congenital rubella
Prematurity
Treatment for Rocky Mountain Spotted Fever
ALWAYS Doxy.
Nothing else works. We usually don’t give doxy to kids under 8, but we do for RMSF.
Treatment for Lyme by categories
Under age 8: Amoxicillin
8 or older: Doxycycline
If there is any meningitis, ceftriaxone.
Unless you have a good reason not to, you should generally do ___ prior to LP
Non-contrast CT of head
They might give you some exam signs that ‘tell you’ that there is not increased ICP, but if they don’t then you need to do it.
First step in management of epiglottitis
Intubate in the OR
(in case there needs to be emergent tracheostomy)
Buzz words for chlamydia pneumonia
“Stoccato cough”
“Peripheral eosinophilia”
“Associated mucopurulent conjunctavitis”
Presentation of acute bronchitis
Funky cough, sputum, fever
Only rhonchi on lung exam with no focal signs or rales.
No peripheral leukocytosis.
Treatment of contacts in pertussis
Also get erythromycin
A febrile UTI is __ until proven otherwise
A febrile UTI is pyelonephritis until proven otherwise
In order to get a clean catch urine sample from very young kiddos, they must be . . .
. . . catheterized
Indications for VCUG
- UTI in a male
- UTI in a female younger than 5
- Any recurrent UTI
Nevus simplex
Those that occur on face will regress. Those that occur on neck will stay.
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Nevus sebaceous
- Orange colored
- Area of alopecia
- Nodule/raised
- Need to be removed before adolescence – risk of cancer later in life
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Features of physiologic jaundice
Should not go above ~12-15 at highest
Gone by DOL#5
Baby is born with indirect hyperbilirubinemia. Likely etiology?
Hemolysis
Direct hyperbilirubinemia in a baby. First steps?
Rule out infection: Blood cx, urine cx, SCF cx
When do you repair a diaphragmatic hernia? What might you need?
3-4 days after birth – NOT immediately
ECMO may be necessary.
CHARGE syndrome
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Prenatal things you can test for that are associated with RDS at birth
L:S ratio < 2 (as lungs mature, lecithin increases and sphingomyelin decreases)
Low phosphatidylglycerol
Big tongue + umbilical hernia
Hypothyroidism
Barium enema for intussusception
Diagnostic and therpaeutic
What don’t you do to a baby with hypospadias?
Circumsize
Congenital varicella
Born w/ pox scars
Cortical atrophy
Limb hypoplasia
When does baby get VZV Ig?
If mom has Sx of varicella 5d before to 2d after delivery
Chlamydia conjunctavitis can lead to __ if untreated
Chlamydia conjunctavitis can lead to chamlydia pneumonia or blindness if untreated
Coarctation of the aorta is associated with. . .
. . . Turner’s
Pierre-Robins sequence
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Williams syndrome vs Smith-Magenis syndrome
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“No tonsils”
No B cells
Bruton’s or SCID (if there is also no thymus!)
Cornelia de Lange Syndrome
Slow growth before and after birth leading to short stature; intellectual disability that is usually moderate to severe.
Also with severe forearm and hand abnormalities. Often missing multiple fingers or with V-shaped hand.
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Truncus arteriosus is tightly linked to __.
Truncus arteriosus is tightly linked to DiGeorge syndrome.
Weight after birth
- Birth: BW
- 7d: BW - 10%
- 2 wks: BW
- 6 mo: 2x BW
- 1 yr: 3x BW
Dominant protein and fat in breast milk
Protein: Whey
Fat: Long-chain
Bone age in obesity
Bone age > chronological age
Due to the effects of extrogen produced by adipocyte aromatase
Thus, final height is reduced in childhood obesity
Bone age in precocious puberty
Bone age > chronological age
Due to sex hormones (estrogen or testosterone) produced by gonads
Thus, final height less than predicted height
Bone age in hyperthyroidism
Bone age > chronologic age
Think of the hyperthyroid as causing bone to move along faster than usual. This ultimately results in shorter stature.
PTLD and rejection
“If you have PTLD, you can’t reject. If you are rejecting, you can’t have PTLD.”
Neonatal renal cysts
Nephronophthisis
Problems w/ renal epithelial cell polarization. Results in scarring of renal tubules.
Presents in adolescents with pyuria, scarring, ESRD if not caught early in life.
Antibodies in T1DM
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Things to do prior to discharge after BRUE
- CPR training of parents
- PMD followup scheduled
Canavan disease
- Spongiform leukoencephalopathy
- Due to abnormal metabolism and buildup of N-acetylaspartic acid (NAA), which accumulates in brain
- Is detectable in urine for diagnosis
- Missing enzyme is aspartoacylase
- Autosomal recessive
- Occurs in Ashkenazi Jewish populations
Low risk vs high risk BRUE management
Low risk: ED obs, 1-6 hrs, 2 feedings
High risk: Admit for CR monitoring 6-24 hrs, 2 feedings, sleep, and wake states
FPIES
- Food protein induce enterocolitis syndrome
- Non-IgE-mediated hypersensitivity
- Presents as chronic watery diarrhea w/ acute intermittent vomiting (immediately after consumption of trigger)
- Begins early in infancy – within one to four weeks following introduction of cow’s milk (CM) or soy protein. Usually first 6 months of life.
- ~30% have atopy too
- Treat w/ elimination diet
Children < age 5 get __ for pneumonia
Children < age 5 get amoxicillin for pneumonia
Lyme meningitis CSF looks a lot like. . .
. . . viral meningitis CSF
Often with even less WBC
Causes of meningitis in infants < 1 month of age
- GBS
- E. coli
- Other gram negative bacilli
- HSV
- Listeria
- Strep pneumoniae
- Treat w/ ampicillin + cefotaxime
Causes of meningitis in infants between 1-2 months of age
- E. coli
- Strep pneumoniae
- Enterovirus
- HIB
- GBS
-
Treat w/ vancomycin + ceftriaxone
- or vancomycin + meropenem
Causes of meningitis in children 2 months - 6 years of age
- Strep pneumoniae
- N. meningitides
- Enterovirus
- Borrelia (Lyme)
- HIB
-
Treat w/ vancomycin + ceftriaxone
- or vancomycin + meropenem
Causes of meningitis in children 6 years-adolescence
- S. pneumoniae
- N. meingitides
- Enterovirus
- Lyme
-
Treat w/ vancomycin + ceftriaxone
- or vancomycin + meropenem
Master meningitis table
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